Data for: "Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa"
(2026).
Data for: "Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005150.
Dataset containing results of an investigation to determine the prevalence of tuberculosis (TB) among enrolled participants of the TREATS study between February 19 and August 11, 2019. Participants were aged 15 years and over and located in one of 3 communities in Zambia or 1 community in South Africa. TB was detected using point-of-care C-reactive protein testing, alone and combined with symptom screening, that covered self-reported symptoms for cough, fever, chest pain, night sweats, and weight loss.
This is the minimal dataset required to conduct the analysis presented in the published paper:
Ruperez M, Shanaube K, Mureithi L, Wapamesa C, Burnett MJ, Kosloff B, de Haas P, Hayes R, Fidler S, Gachie T, Schaap A, Floyd S, Klinkenberg E, Ayles H; TREATS study team. Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa. Lancet Glob Health. 2023 May;11(5):e704-e714. doi: 10.1016/S2214-109X(23)00113-4. Erratum in: Lancet Glob Health. 2023 Jul;11(7):e1011. doi: 10.1016/S2214-109X(23)00222-X. PMID: 37061309.
The study protocol and ICF were approved by LSHTM Ethics Committee (ref: 14905) as well as the University of Zambia Biomedical Research Ethics Committee (ref: 005–02–18) and Pharma-Ethics Ltd in South Africa (ref: 180219727).
Additional Information
Data is made available in two forms: (1) an open access data that has been processed to broaden participant demographics, and a (2) controlled access dataset that contains additional information. Consult codebook for information.
Keywords
Tuberculosis; C-reactive Protein.; Screening; Community| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | Data was captured at the TREATS TB prevalence survey in the community at time of participant's enrolment and next day visit through electronic data capturing (EDC) tools designed for that purpose. Socio-demographic and clinical characteristics were collected through a standardized questionnaire. Point-of-care CRP and HIV test results were also captured at the time of enrolment in the EDC tool, as well as the CAD score from the Chest-X ray. Results from Xpert tests and culture were captured by the laboratory information and management system in place in each of the sites and merged to rest of the data through study-id number. Informed consent and questionnaires were also translated in to local languages such as Nyanja and Bemba in Zambia and Xhosa in South Africa. |
| Capture method | Questionnaire, Lab observation: Participant, Physical measurements and tests |
| Collection Period |
From To 19 February 2019 11 August 2019 |
| Date | 15 April 2026 |
| Language(s) of written materials | English |
| Creator(s) |
Ruperez Larrea, M
|
| Associated roles | Ayles, H (Principal Investigator); Floyd, S (Co-Investigator); Hayes, R (Co-Investigator); Schaap, A (Co-Investigator); Klinkenberg, E (Co-Investigator); Gachie, T (Co-Investigator); Kosloff, B (Co-Investigator); Shanaube, K (Co-Investigator); de Haas, P (Researcher); Fidler, S (Researcher); Mureithi, L (Researcher); Wapamesa, C (Researcher) and Burnett, JM (Researcher) |
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Research Centre | TB Centre |
| Research Group | TREATS project |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; Zambart, University of Zambia, Lusaka, Zambia; Health Systems Trust; KNCV Tuberculosis Foundation, The Hague, Netherlands; Imperial College, London, United Kingdom; London School of Economics, London, United Kingdom; University of Sheffield, Sheffield, United Kingdom; Delft Imaging; QIAGEN; The Union |
| Funders |
Project Funder Grant Number Funder URI TREATS RIA2016S-1632 https://doi.org/10.13039/501100001713 |
| Date Deposited | 15 Apr 2026 11:07 |
| Last Modified | 15 Apr 2026 11:44 |
| Publisher | London School of Hygiene & Tropical Medicine |
Explore Further
- Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa.
- Clinical outcomes of participants of a TB prevalence survey with an abnormal chest X-ray but no evidence of TB disease after a median follow-up of 9 months in Zambia and South Africa.
- Tuberculosis prevalence after 4 years of population-wide systematic TB symptom screening and universal testing and treatment for HIV in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: A cross-sectional survey (TREATS).
Data / Code
-
subject - Data
-
- Available under Creative Commons: Attribution 4.0
-
info - Dataset underpinning research on the performance of CRP as a screening tool for TB analysis
grid_on - text/csv
- folder_info
- 1MB
-
subject - Data
-
lock - Restricted to Request access for all
-
copyright - Available under Data Sharing Agreement
-
info - Controlled access dataset - consult codebook for details
folder_zip - application/zip
- folder_info
- 241B
Documentation
-
subject - Documentation
-
- Available under Creative Commons: Attribution 4.0
-
info - Codebook for data collected to assess performance of CRP as a screening tool for TB analysis
html - text/html
- folder_info
- 27kB
