Effect of intra-partum azithromycin on gut microbiome development in early childhood

Intrapartum azithromycin is being evaluated as a potential intervention for preventing maternal sepsis and mortality. This study evaluated the effect of intrapartum azithromycin on the development of the child gut microbiome over the first 3 years of life. The study used samples from healthy Gambian children who were recruited in the PregnAnZI-2 trial (ClinicalTrials.org NCT03199547). PregnAnZI-2 was a large clinical trial conducted in The Gambia and Burkina Faso to assess the effect of 2g oral azithromycin given to women during labour, on neonatal sepsis and mortality.

Alternative Title

PRJNA1129542

Keywords

Intrapartum azithromycin; Sepsis