Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
Awalt, JK
; Ooi, ZK; Ashton, TD; Mansouri, M; Calic, PPS; Zhou, Q; Vasanthan, S; Lee, S; Loi, K; Jarman, KE; Penington, JS; Qiu, D; Zhang, X; Lehane, AM; Mao, EY; Gancheva, MR; Wilson, DW; Giannangelo, C; MacRaild, CA; Creek, DJ; Yeo, T; Sheth, T; Fidock, DA; Churchyard, A; Baum, J; Famodimu, MT; Delves, MJ; Kristan, M; Stewart, L; Sutherland, CJ; Coyle, R; Jagoe, H; Lee, MCS; Chowdury, M; de Koning-Ward, TF; Baud, D; Brand, S; Jackson, PF; Cowman, AF; Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
; Ooi, ZK; Ashton, TD; Mansouri, M; Calic, PPS; Zhou, Q; Vasanthan, S; Lee, S; Loi, K; Jarman, KE; Penington, JS; Qiu, D; Zhang, X; Lehane, AM; Mao, EY; Gancheva, MR; Wilson, DW; Giannangelo, C; MacRaild, CA; Creek, DJ; Yeo, T; Sheth, T; Fidock, DA; Churchyard, A; Baum, J; Famodimu, MT; Delves, MJ; Kristan, M; Stewart, L; Sutherland, CJ; Coyle, R; Jagoe, H; Lee, MCS; Chowdury, M; de Koning-Ward, TF; Baud, D; Brand, S; Jackson, PF; Cowman, AF; Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
Supporting files for "Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4". This include metabolomics data (XLSX); Molecular Formula Strings (CSV); Crystal structure (PDB); and a file containing Caco-2 data, P. falciparum and P. knowlesi asexual (parental and drug-resistant lines) and gamete dose response data, MIR, AReBar, metabolomic, standard membrane feeding assay, mouse model and plasma exposure data, and compound spectra (PDF).
Keywords
Alkyls; Antimicrobial agents; Assays; Indoles; Parasites| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment: Laboratory |
| Date | 15 April 2025 |
| Language(s) of written materials | English |
| Creator(s) |
Awalt, JK; Ooi, ZK; Ashton, TD; Mansouri, M; Calic, PPS; Zhou, Q; Vasanthan, S; Lee, S; Loi, K; Jarman, KE; Penington, JS; Qiu, D; Zhang, X; Lehane, AM; Mao, EY; Gancheva, MR; Wilson, DW; Giannangelo, C; MacRaild, CA; Creek, DJ; Yeo, T; Sheth, T; Fidock, DA; Churchyard, A; Baum, J; Famodimu, MT; Delves, MJ; Kristan, M; Stewart, L; Sutherland, CJ; Coyle, R; Jagoe, H; Lee, MCS; Chowdury, M; de Koning-Ward, TF; Baud, D; Brand, S; Jackson, PF; Cowman, AF; Dans, MG and Sleebs, BE
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Research Centre | Malaria Centre |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 08 Aug 2025 15:13 |
| Last Modified | 08 Aug 2025 15:18 |
| Publisher | ACS Publications |
No files available. Please consult associated links.
