Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachel; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Awalt, JK

; Ooi, ZK

; Ashton, TD

; Mansouri, M

; Calic, PPS

; Zhou, Q; Vasanthan, S; Lee, S; Loi, K; Jarman, KE; Penington, JS

; Qiu, D; Zhang, X; Lehane, AM

; Mao, EY; Gancheva, MR; Wilson, DW; Giannangelo, C

; MacRaild, CA

; Creek, DJ

; Yeo, T; Sheth, T; Fidock, DA; Churchyard, A; Baum, J; Famodimu, MT

; Delves, MJ

; Kristan, M

; Stewart, L; Sutherland, CJ

; Coyle, R; Jagoe, H; Lee, MCS; Chowdury, M; de Koning-Ward, TF; Baud, D

; Brand, S; Jackson, PF; Cowman, AF; Dans, MG and Sleebs, BE

(2025). Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4. [Dataset]. ACS Publications. https://doi.org/10.1021/acs.jmedchem.5c00614

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Supporting files for "Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4". This include metabolomics data (XLSX); Molecular Formula Strings (CSV); Crystal structure (PDB); and a file containing Caco-2 data, P. falciparum and P. knowlesi asexual (parental and drug-resistant lines) and gamete dose response data, MIR, AReBar, metabolomic, standard membrane feeding assay, mouse model and plasma exposure data, and compound spectra (PDF).

Keywords

Alkyls; Antimicrobial agents; Assays; Indoles; Parasites

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Experiment: Laboratory
Date	15 April 2025
Language(s) of written materials	English
Creator(s)	Awalt, JK; Ooi, ZK; Ashton, TD; Mansouri, M; Calic, PPS; Zhou, Q; Vasanthan, S; Lee, S; Loi, K; Jarman, KE; Penington, JS; Qiu, D; Zhang, X; Lehane, AM; Mao, EY; Gancheva, MR; Wilson, DW; Giannangelo, C; MacRaild, CA; Creek, DJ; Yeo, T; Sheth, T; Fidock, DA; Churchyard, A; Baum, J; Famodimu, MT ; Delves, MJ ; Kristan, M ; Stewart, L; Sutherland, CJ ; Coyle, R; Jagoe, H; Lee, MCS; Chowdury, M; de Koning-Ward, TF; Baud, D; Brand, S; Jackson, PF; Cowman, AF; Dans, MG and Sleebs, BE
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre	Malaria Centre
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Wellcome Trust UNSPECIFIED http://dx.doi.org/10.13039/100010269
Date Deposited	08 Aug 2025 15:13
Last Modified	25 Jun 2026 12:31
Publisher	ACS Publications