Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
Awalt, JK
, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
Supporting files for "Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4". This include metabolomics data (XLSX); Molecular Formula Strings (CSV); Crystal structure (PDB); and a file containing Caco-2 data, P. falciparum and P. knowlesi asexual (parental and drug-resistant lines) and gamete dose response data, MIR, AReBar, metabolomic, standard membrane feeding assay, mouse model and plasma exposure data, and compound spectra (PDF).
Keywords
Alkyls, Antimicrobial agents, Assays, Indoles, Parasites| Item Type | Dataset |
|---|---|
| Capture method | Experiment: Laboratory |
| Date | 15 April 2025 |
| Language(s) of written materials | English |
| Creator(s) |
Awalt, JK, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Research Centre | Malaria Centre |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 08 Aug 2025 15:13 |
| Last Modified | 08 Aug 2025 15:18 |
| Publisher | ACS Publications |
No files available. Please consult associated links.
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