Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
Awalt, JK
, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
(2025).
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.5c00614
Supporting files for "Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4". This include metabolomics data (XLSX); Molecular Formula Strings (CSV); Crystal structure (PDB); and a file containing Caco-2 data, P. falciparum and P. knowlesi asexual (parental and drug-resistant lines) and gamete dose response data, MIR, AReBar, metabolomic, standard membrane feeding assay, mouse model and plasma exposure data, and compound spectra (PDF).
Keywords
Alkyls; Antimicrobial agents; Assays; Indoles; Parasites| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment: Laboratory |
| Date | 15 April 2025 |
| Language(s) of written materials | English |
| Creator(s) |
Awalt, JK, Ooi, ZK, Ashton, TD, Mansouri, M, Calic, PPS, Zhou, Q, Vasanthan, S, Lee, S, Loi, K, Jarman, KE, Penington, JS, Qiu, D, Zhang, X, Lehane, AM, Mao, EY, Gancheva, MR, Wilson, DW, Giannangelo, C, MacRaild, CA, Creek, DJ, Yeo, T, Sheth, T, Fidock, DA, Churchyard, A, Baum, J, Famodimu, MT, Delves, MJ, Kristan, M, Stewart, L, Sutherland, CJ, Coyle, R, Jagoe, H, Lee, MCS, Chowdury, M, de Koning-Ward, TF, Baud, D, Brand, S, Jackson, PF, Cowman, AF, Dans, MG and Sleebs, BE
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Research Centre | Malaria Centre |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 08 Aug 2025 15:13 |
| Last Modified | 08 Aug 2025 15:18 |
| Publisher | ACS Publications |
No files available. Please consult associated links.
