Data supporting "Helminth-driven gut inflammation and microbial translocation are linked to altered vaccine responses in rural Uganda"

This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting). Variables include data on socio-demographic characteristics, helminth infections, vaccine-specific responses, and stool and plasma markers of gut inflammation and microbial translocation.

Additional Information

To access the data, requests must be made to the POPVAC A trial PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC A investigator team. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.

Keywords

Vaccine responses, Schistosoma mansoni, Gut inflammation, Gut microbial translocation, Helminth infections