10.17037/DATA.00004505
This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting). Variables include data on socio-demographic characteristics, helminth infections, vaccine-specific responses, and stool and plasma markers of gut inflammation and microbial translocation.
To access the data, requests must be made to the POPVAC A trial PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC A investigator team. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| random_id | Unique ID number | 1 to 478 | Numeric | |
| age | Participant age in years | 9 to 17 | Numeric | |
| sex | Participant sex | Numeric | ||
| Male | 1 | |||
| Female | 2 | |||
| caa_screening_caa | CAA concentration at screening timepoint, pg/ml | 0 through 404684.3 | Numeric | |
| result_screening_caa | S. mansoni infection status, based on CAA concentration at screening timepoint (cutoff 30 pg/ml) | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| caa_week0_caa | CAA concentration at week 0, pg/ml | 0 through 1726387 | Numeric | |
| result_week0_caa | S. mansoni infection status, based on CAA concentration at the week 0 timepoint (cutoff 30 pg/ml) | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| caa_week8_caa | CAA concentration at week 8, pg/ml | 0 through 217636.2 | Numeric | |
| result_week8_caa | S. mansoni infection status, based on CAA concentration at the week 8 timepoint (cutoff 30 pg/ml) | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| fabp2_wk0 | I-FABP2 concentration (pg/ml), measured at the week 0 timepoint | 0 through 258.54 | Numeric | |
| lbp_wk0 | LBP concentration (µg/ml), measured at the week 0 timepoint | 0 through 42.096 | Numeric | |
| endocab_IgG_wk0 | EndoCab IgG concentration (gmu/ml), measured at the week 0 timepoint | 13 through 2342.5 | Numeric | |
| endocab_IgM_wk0 | EndoCab IgM concentration (mmu/ml), measured at the week 0 timepoint | 4.7481 through 305.8776 | Numeric | |
| fob_wk8 | Fecal occult blood concentration (µg/ml), measured at the week 8 timepoint | 0 through 5250 | Numeric | |
| lcn2_wk8 | Fecal lipocalin-2 concentration (ng/ml), measured at the week 8 timepoint | 0 through 5968.8 | Numeric | |
| trialarm | Standard (STD) or Intensive (INT) anthelminthic treatment arm | Numeric | ||
| Standard | 0 | |||
| Intensive | 1 | |||
| bcg_w0 | BCG administration at week 0 | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| yf_w4 | Yellow Fever administration at week 4 | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| hpv_w4 | HPV administration at week 4 | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| ty_w4 | Administration of at least one of 3 oral typhoid doses, at the week 4 timepoint | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| td_w28 | Tetanus/Diptheria administration at week 28 | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| tt_IgG_baseline | Tetanus toxoid-specific IgG (IU/ml), measured at week 28 | 0.0015 through 21.0075 | Numeric | |
| dt_IgG_baseline | Diptheria toxoid-specific IgG (IU/ml), measured at week 28 | 0 through 4.2345 | Numeric | |
| tt_IgG_week52 | Tetanus toxoid-specific IgG (IU/ml), measured at week 52 | 0.006 through 151.458 | Numeric | |
| dt_IgG_week52 | Diptheria toxoid-specific IgG (IU/ml), measured at week 52 | 0 through 9.45 | Numeric | |
| bcg_week0 | BCG-specific IFN-Ɣ response (SFUs per a million PBMCs), measured by ELISpot at week 0 | 0 through 645 | Numeric | |
| qc_0 | Week 0: Did result pass QC (≤83.333 SFUs/10^6 PBMCs in each of the two unstimulated wells)? | String | ||
| Fail | fail | |||
| Pass | pass | |||
| bcg_week8 | BCG-specific IFN-Ɣ response (SFUs per a million PBMCs), measured by ELISpot at week 8 | 0 through 1045 | Numeric | |
| qc_8 | Week 8: Did result pass QC (≤83.333 SFUs/10^6 PBMCs in each of the two unstimulated wells)? | String | ||
| Fail | fail | |||
| Pass | pass | |||
| bcg_week52 | BCG-specific IFN-Ɣ response (SFUs per a million PBMCs), measured by ELISpot at week 52 | 0 through 768.3333 | Numeric | |
| qc_52 | Week 52: Did result pass QC (≤83.333 SFUs/10^6 PBMCs in each of the two unstimulated wells)? | String | ||
| Fail | fail | |||
| Pass | pass | |||
| yfprnt_50_wk0 | Yellow Fever PRNT50 titres, week 0 | 5 through 2320 | Numeric | |
| yfprnt_90_wk0 | Yellow Fever PRNT90 titres, week 0 | 5 through 80 | Numeric | |
| yfprnt_50_wk8 | Yellow Fever PRNT50 titres, week 8 | 20 through 20480 | Numeric | |
| yfprnt_90_wk8 | Yellow Fever PRNT90 titres, week 8 | 5 through 10240 | Numeric | |
| yfprnt_50_wk52 | Yellow Fever PRNT50 titres, week 52 | 20 through 20480 | Numeric | |
| yfprnt_90_wk52 | Yellow Fever PRNT90 titres, week 52 | 5 through 5120 | Numeric | |
| typhi_igg_wk0 | S. typhi O:LPS-specific IgG (EU/ml), Week 0 | 5.76 through 4589.44 | Numeric | |
| typhi_igg_wk8 | S. typhi O:LPS-specific IgG (EU/ml), Week 8 | 8.32 through 6631.68 | Numeric | |
| typhi_igg_wk52 | S. typhi O:LPS-specific IgG (EU/ml), Week 52 | 0 through 3544.64 | Numeric | |
| hpv16_wk0 | HPV-16-specific IgG concentration (EU/ml) at week 0 | 0.3 through 326.4 | Numeric | |
| hpv18_wk0 | HPV-18-specific IgG concentration (EU/ml) at week 0 | 0 through 5863.2 | Numeric | |
| hpv16_wk8 | HPV-16-specific IgG concentration (EU/ml) at week 8 | 0 through 4300.8 | Numeric | |
| hpv18_wk8 | HPV-18-specific IgG concentration (EU/ml) at week 8 | 33.2 thtough 13841.6 | Numeric | |
| hpv16_wk52 | HPV-16-specific IgG concentration (EU/ml) at week 52 | 0.4 through 4300.8 | Numeric | |
| hpv18_wk52 | HPV-18-specific IgG concentration (EU/ml) at week 52 | 0 through13841.6 | Numeric | |
| necres | N. americanus infection status, PCR, screening timepoint | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| ssres | S. stercoralis infection status, PCR, screening timepoint | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| fcal_wk8_combined_ugml | Fecal calprotectin concentration (µg/ml), measured at the week 8 timepoint | 0 through 1312.287 | Numeric | |
| cd14_wk0_combined_ugml | soluble CD14 concentration (µg/ml), measured at the week 8 timepoint | 0 through 4.196875 | Numeric | |
| anyworm | Infection with any of S. mansoni, hookworm or S. stercoralis at week 0 (screening result for hookworm and Strongyloides used) | Numeric | ||
| Uninfected | 0 | |||
| Any helminth infection | 1 | |||