Lifetime PBK model for PFOA and PFOS

Kalina, JORCID logo; Jiří, K; Sapunova, DORCID logo; Vogs, CORCID logo; Deepika; Kumar, V; Westerhout, JORCID logo; Ratier, AORCID logo; Pachoulide, CORCID logo; Kruisselbrink, JORCID logo; Engel, JORCID logo; Fletcher, TORCID logo; Andersson, AORCID logo; Piler, PORCID logo; Šenk, P and Komprdová, KORCID logo (2026). Lifetime PBK model for PFOA and PFOS. [Dataset]. Zenodo. https://doi.org/10.5281/zenodo.21718716
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The validated EFSA lifetime PBK model modified by Westerhout with 9 compartments (lung, skin, blood (arterial, venous), gut, liver, fat, kidney, filtrate and rest of the body) modified by incorporating excretion via menstrual blood and feces and extended to a lifetime framework, allowing simulations to be performed from birth while accounting for age-dependent changes in all physiological parameters.

Keywords

EFSA

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