Screening and treatment of malaria in pregnancy in West Africa
The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach. The study conducted an open, individually randomized, non-inferiority trial of IPTp-SP versus ISTp in 5,354 primi- or secundigravidae in The Gambia, Mali, Burkina Faso and Ghana.
Alternative Title
A non-inferiority, individually randomized trial of intermittent screening and treatment versus intermittent preventive treatment in the control of malaria in pregnancy
Additional Information
Trial registration: ClinicalTrials.gov (NCT01084213); Pan African Clinical trials Registry (PACT201202000272122)
Keywords
Malaria; Pregnancy; Intermittent Preventive Treatment in Pregnancy; Intermittent Screening and Treatment in Pregnancy; IPTp; ISTpItem Type | Dataset |
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Resource Type |
Resource Type Resource Description Dataset Quantitative |
Capture method | Experiment: Field Intervention |
Collection Period |
From To 2010 2012 |
Date | May 2015 |
Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude 13.4448 -15.3071 13.44 -15.3135 |
Language(s) of written materials | English, French |
Creator(s) |
Cairns, M |
Associated roles | Bojang, K (Project Leader), Coulibaly, SO (Project Leader), Kayentao, K (Project Leader), Williams, J (Project Leader), Abubakar, I (Data Manager), Akor, F (Researcher), Mohammed, K (Researcher), Bationo, R (Researcher), Dabira, E (Researcher), Soulama, A (Researcher), Djimdé, M (Researcher), Guirou, E (Researcher), Awine, T (Data Manager), Quaye, S (Researcher), Njie, F (Researcher), Ordi, J (Researcher), Doumbo, O (Researcher), Hodgson, A (Researcher), Oduro, A (Researcher), Meshnick, S (Researcher), Taylor, S (Researcher), Magnussen, P (Researcher), Kuile, Ft (Project Leader), Milligan, P (Project Leader), Chandramohan, D (Project Leader) and Greenwood, B (Project Leader) |
LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Participating Institutions | London School of Hygiene & Tropical Medicine; Kwame Nkrumah University of Science and Technology; University of Ouagadougou; University of Bamako; Navrongo Health Research Centre; Hospital Clinic-Universitat de Barcelona; University of North Carolina; Duke University; University of Copenhagen; Liverpool School of Tropical Medicine |
Funders |
Project Funder Grant Number Funder URI Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine Versus Intermittent Screening and Treatment of Malaria in Pregnancy in West Africa (IPTp-SP vs. ISTp) IP.2007.31080.003 UNSPECIFIED UNSPECIFIED UNSPECIFIED http://dx.doi.org/10.13039/501100000278 |
Date Deposited | 28 May 2015 14:04 |
Last Modified | 27 Jan 2025 14:21 |
Publisher | London School of Hygiene & Tropical Medicine |