Zirimenya, L, Natukunda, N, Nassuuna, N, Nkurunungi, G, Elliott, AM and Webb, E. 2024. Data supporting "The effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on vaccine-specific responses among schoolchildren in rural Uganda: results of the POPVAC B randomised, controlled trial". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00003759.
Zirimenya, L, Natukunda, N, Nassuuna, N, Nkurunungi, G, Elliott, AM and Webb, E. Data supporting "The effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on vaccine-specific responses among schoolchildren in rural Uganda: results of the POPVAC B randomised, controlled trial" [Internet]. London School of Hygiene & Tropical Medicine; 2024. Available from: https://doi.org/10.17037/DATA.00003759.
Zirimenya, L, Natukunda, N, Nassuuna, N, Nkurunungi, G, Elliott, AM and Webb, E (2024). Data supporting "The effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on vaccine-specific responses among schoolchildren in rural Uganda: results of the POPVAC B randomised, controlled trial". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00003759.
Description
This dataset comprises individual-level data from participants in the POPVAC B randomised controlled trial. POPVAC B was a randomised, double-blind, placebo-controlled trial of the effect of malaria IPT with dihydroartemisinin-piperaquine (DP) on vaccine responses among schoolchildren (9-17 years) in Jinja district, Uganda (ISRCTN62041885).
The aim of the trial was to comprehensively address the hypothesis that malaria infection causes suppression of responses to unrelated vaccines and that this effect can be reversed at least partially, by monthly intermittent preventive treatment (IPT) of malaria in high-transmission settings.
A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of IPT of malaria on immune response to vaccines with different characteristics.
Additional information
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
Data capture method | Questionnaire, Lab observation | ||||
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Data Collection Period |
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Date (Date submitted to LSHTM repository) | 29 January 2024 | ||||
Language(s) of written materials | English |
Data Creators | Zirimenya, L, Natukunda, N, Nassuuna, N, Nkurunungi, G, Elliott, AM and Webb, E |
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Associated roles | Zziwa, C (Researcher), Ninsiima, C (Researcher), Kukundakwe, C (Researcher), Katushabe, C (Researcher), Namusobya, L (Researcher), Oduru, G (Researcher), Kabami, G (Researcher), Kabali, J (Researcher), Kayiwa, J (Researcher), Kabagenyi, J (Researcher), Cose, S (Researcher), Wajja, A (Researcher), Staedke, SG (Researcher) and Kaleebu, P (Researcher) |
LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
Participating Institutions | MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda, London School of Hygiene & Tropical Medicine, London, United Kingdom, Uganda Virus Research Institute, Entebbe, Uganda |
Funders |
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Date Deposited | 02 Feb 2024 14:20 |
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Last Modified | 02 Feb 2024 14:48 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data / Code
Restricted to: Request access for all
Filename: POPVAC_B_data.txt
Description: POPVAC B data on malaria, trial intervention and vaccines
Licence: Data Sharing Agreement
Content type: Dataset
File size: 56B
Mime-Type: text/plain
Documentation
Filename: POPVAC_B_data_codebook.html
Description: POPVAC B data dictionary
Content type: Textual content
File size: 40kB
Mime-Type: text/html
Filename: 3759_UserGuide.html
Description: User guide for POPVAC B dataset
Content type: Textual content
File size: 8kB
Mime-Type: text/html