Data supporting "The effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on vaccine-specific responses among schoolchildren in rural Uganda: results of the POPVAC B randomised, controlled trial" – User Guide

Persistent identifier

10.17037/DATA.00003759

Description

This dataset comprises individual-level data from participants in the POPVAC B randomised controlled trial. POPVAC B was a randomised, double-blind, placebo-controlled trial of the effect of malaria IPT with dihydroartemisinin-piperaquine (DP) on vaccine responses among schoolchildren (9-17 years) in Jinja district, Uganda (ISRCTN62041885). The aim of the trial was to comprehensively address the hypothesis that malaria infection causes suppression of responses to unrelated vaccines and that this effect can be reversed at least partially, by monthly intermittent preventive treatment (IPT) of malaria in high-transmission settings. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of IPT of malaria on immune response to vaccines with different characteristics.

Data collection methods

Data collection process outlined in “The effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on vaccine-specific responses among schoolchildren in rural Uganda: results of the POPVAC B randomised, controlled trial".

Geographic regions

Jinja district, Uganda

Key dates

• Data collection period: 25 May 2021 - 6 September 2022
• Date submitted to repository: 29 January 2024

Population

Schoolchildren, aged 9-17 years, in Jinja district, Uganda.

Ethics

Keywords

Malaria, Dihydroartemisinin–piperaquine, Vaccine response, Children, Randomised controlled trial

Language of written material

English

Project information

Creators

Associated roles

File description