; Nassuuna, J; Natukunda, A; Zirimenya, L; Webb, E and Elliott, A
(2024).
Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00003758.
This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was an open-label randomised controlled trial of intensive versus standard intervention against Schistosoma mansoni among schoolchildren (9-17 years) in Koome islands, Uganda (ISRCTN60517191).
The aim of the trial was to comprehensively address the hypothesis that Schistosoma mansoni infection causes suppression of responses to unrelated vaccines and that this effect can be reversed by intensive treatment with praziquantel.
The trial population was selected to comprise children at intense risk of exposure to Schistosoma mansoni infection in a “hot-spot”, island setting in Lake Victoria, Uganda.
A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of intensive treatment of Schistosoma mansoni on immune response to vaccines with different characteristics.
Additional Information
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
Keywords
Schistosoma mansoni; Praziquantel; Vaccine response; Children; Randomised controlled trial| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Questionnaire, Lab observation |
| Collection Period |
From To July 2019 October 2020 |
| Date | 29 January 2024 |
| Language(s) of written materials | English |
| Creator(s) |
Nkurunungi, G; Nassuuna, J; Natukunda, A; Zirimenya, L; Webb, E and Elliott, A
|
| Associated roles | Zziwa, C (Researcher); Ninsiima, C (Researcher); Kabagenyi, J (Researcher); Kabuubi, P (Researcher); van Dam, G (Researcher); Corstjens, P (Researcher); Kayiwa, J (Researcher); Kizza, M (Researcher); Mutebe, A (Researcher); Nakazibwe, E (Researcher); Akello, F (Researcher); Sewankambo, M (Researcher); Kiwanuka, S (Researcher); Cose, S (Researcher); Wajja, A (Researcher) and Kaleebu, P (Researcher) |
| LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
| Participating Institutions | MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda; London School of Hygiene & Tropical Medicine, London, United Kingdom; Leiden University Medical Centre, Leiden, Netherlands |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 02 Feb 2024 14:12 |
| Last Modified | 21 Aug 2025 09:52 |
| Publisher | London School of Hygiene & Tropical Medicine |
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subject - Data
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lock - Restricted to Request access for all
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copyright - Available under Data Sharing Agreement
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