Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial" – Data codebook

10.17037/DATA.00003758

Description

This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was an open-label randomised controlled trial of intensive versus standard intervention against Schistosoma mansoni among schoolchildren (9-17 years) in Koome islands, Uganda (ISRCTN60517191). The aim of the trial was to comprehensively address the hypothesis that Schistosoma mansoni infection causes suppression of responses to unrelated vaccines and that this effect can be reversed by intensive treatment with praziquantel. The trial population was selected to comprise children at intense risk of exposure to Schistosoma mansoni infection in a “hot-spot”, island setting in Lake Victoria, Uganda. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of intensive treatment of Schistosoma mansoni on immune response to vaccines with different characteristics.

Data access statement

To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.

Data codebook

The following variables are contained within the POPVAC A dataset.

Variable name Variable description Answer label Answer code Variable type
age Participant's age in year (age placed in categories where fewer participants)     String
    Age 9 9  
    Age 12 12  
    Age 10 10  
    Age 13 13  
    Age 11 11  
    Age 14 14  
    Age 15-17 15-17  
sex Participant's sex        String
    Male    
    Female    
         
trialarm Trial arm     String
    Standard    
    Intensive    
bcg_w0 BCG administered at week 0     String
    Yes Yes  
    Missing .  
         
yf_w4 Yellow fever vaccine administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
hpv_w4 HPV vaccine administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d1_w4 Oral typhoid dose 1 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d2_w4 Oral typhoid dose 2 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d3_w4 Oral typhoid dose 3 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
hpv_w8 HPV vaccine administered at week 8     String
    Yes Yes  
    No No  
    Missing .  
td_w28 Tetanus-diphtheria administered at week 28     String
    Yes Yes  
    No No  
    Missing .  
hpv_w28 HPV vaccine administered at week 28     String
    Yes Yes  
    No No  
    Missing .  
td_w52 Tetanus-diphtheria administered at week 52     String
    Yes Yes  
    No No  
    Missing .  
pzq_wpre6 Praziquantel administered 6 weeks before BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_wpre4 Praziquantel administered 4 weeks before BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_wpre2 Praziquantel administered 2 weeks before BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_w8 Praziquantel administered 8 weeks after BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_w20 Praziquantel administered 20 weeks after BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_w44 Praziquantel administered 44 weeks after BCG     String
    Yes Yes  
    No No  
    Missing .  
pzq_w52 Praziquantel administered 52 weeks after BCG     String
    Yes Yes  
    No No  
    Missing .  
caa_screening_caa S. mansoni CAA concentration at screening, pg/ml Continuous    
result_screening_caa S. mansoni CAA result at screening     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
caa_week0_caa S. mansoni CAA concentration at week 0, pg/ml Continuous   Numeric
result_week0_caa S. mansoni CAA result at week 0     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
caa_week8_caa S. mansoni CAA concentration at week 8, pg/ml Continuous   Numeric
         
         
         
result_week8_caa S. mansoni CAA result at week 8     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
caa_week28_caa S. mansoni CAA concentration at week 28, pg/ml Continuous   Numeric
result_week28_caa S. mansoni CAA result at week 28     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
caa_week52_caa S. mansoni CAA concentration at week 52, pg/ml Continuous   Numeric
result_week52_caa S. mansoni CAA result at week 52     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
necres_screen Necator amerianus PCR result at screening     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
smres_screen S. mansoni PCR result at screening     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
ssres_screen Strongyloides stercoralis PCR result at screening     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
necres_wk28 Necator amerianus PCR result at week 28     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
smres_wk28 S. mansoni PCR result at week 28     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
ssres_wk28 Strongyloides stercoralis PCR result at week 28     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
necres_wk52 Necator amerianus PCR result at week 52     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive String
smres_wk52 S. mansoni PCR result at week 52      
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
ssres_wk52 Strongyloides stercoralis PCR result at week 52     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
pfal_res Plasmodium falciparum PCR result at screening     String
    Positive Pos  
    Negative Neg  
    Indecisive indecisive  
tt_IgG_week28 Tetanus toxoid-specific IgG at week 28, IU/ml Continuous   Numeric
dt_IgG_week28 Diphtheria toxoid-specific IgG at week 28, IU/ml Continuous   Numeric
tt_IgG_week52 Tetanus toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
dt_IgG_week52 Diphtheria toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
bcg_week0 IFN-gamma response to BCG at week 0 (SFUs per million PBMCs) Continuous   Numeric
bcg_week8 IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) Continuous   Numeric
bcg_week52 IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) Continuous   Numeric
yfprnt_50_wk0 Yellow fever PRNT 50 titre at week 0 Continuous   Numeric
yfprnt_90_wk0 Yellow fever PRNT 90 titre at week 0 Continuous   Numeric
yfprnt_50_wk8 Yellow fever PRNT 50 titre at week 8 Continuous   Numeric
yfprnt_90_wk8 Yellow fever PRNT 90 titre at week 8 Continuous   Numeric
yfprnt_50_wk52 Yellow fever PRNT 50 titre at week 52 Continuous   Numeric
yfprnt_90_wk52 Yellow fever PRNT 90 titre at week 52 Continuous   Numeric
typhi_igg_wk0 S. typhi O:LPS-specific IgG at week 0, EU/ml Continuous   Numeric
typhi_igg_wk8 S. typhi O:LPS-specific IgG at week 8, EU/ml Continuous   Numeric
typhi_igg_wk52 S. typhi O:LPS-specific IgG at week 52, EU/ml Continuous   Numeric
hpv16_wk0 HPV-16-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv18_wk0 HPV-18-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv16_wk8 HPV-16-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv18_wk8 HPV-18-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv16_wk52 HPV-16-specific IgG concentration at week 52, EU/ml Continuous   Numeric
hpv18_wk52 HPV-18-specific IgG concentration at week 52, EU/ml Continuous   Numeric