10.17037/DATA.00003758
This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was an open-label randomised controlled trial of intensive versus standard intervention against Schistosoma mansoni among schoolchildren (9-17 years) in Koome islands, Uganda (ISRCTN60517191). The aim of the trial was to comprehensively address the hypothesis that Schistosoma mansoni infection causes suppression of responses to unrelated vaccines and that this effect can be reversed by intensive treatment with praziquantel. The trial population was selected to comprise children at intense risk of exposure to Schistosoma mansoni infection in a “hot-spot”, island setting in Lake Victoria, Uganda. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of intensive treatment of Schistosoma mansoni on immune response to vaccines with different characteristics.
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
The following variables are contained within the POPVAC A dataset.
Variable name | Variable description | Answer label | Answer code | Variable type |
age | Participant's age in year (age placed in categories where fewer participants) | String | ||
Age 9 | 9 | |||
Age 12 | 12 | |||
Age 10 | 10 | |||
Age 13 | 13 | |||
Age 11 | 11 | |||
Age 14 | 14 | |||
Age 15-17 | 15-17 | |||
sex | Participant's sex | String | ||
Male | ||||
Female | ||||
trialarm | Trial arm | String | ||
Standard | ||||
Intensive | ||||
bcg_w0 | BCG administered at week 0 | String | ||
Yes | Yes | |||
Missing | . | |||
yf_w4 | Yellow fever vaccine administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w4 | HPV vaccine administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d1_w4 | Oral typhoid dose 1 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d2_w4 | Oral typhoid dose 2 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d3_w4 | Oral typhoid dose 3 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w8 | HPV vaccine administered at week 8 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
td_w28 | Tetanus-diphtheria administered at week 28 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w28 | HPV vaccine administered at week 28 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
td_w52 | Tetanus-diphtheria administered at week 52 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_wpre6 | Praziquantel administered 6 weeks before BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_wpre4 | Praziquantel administered 4 weeks before BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_wpre2 | Praziquantel administered 2 weeks before BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w8 | Praziquantel administered 8 weeks after BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w20 | Praziquantel administered 20 weeks after BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w44 | Praziquantel administered 44 weeks after BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w52 | Praziquantel administered 52 weeks after BCG | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
caa_screening_caa | S. mansoni CAA concentration at screening, pg/ml | Continuous | ||
result_screening_caa | S. mansoni CAA result at screening | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
caa_week0_caa | S. mansoni CAA concentration at week 0, pg/ml | Continuous | Numeric | |
result_week0_caa | S. mansoni CAA result at week 0 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
caa_week8_caa | S. mansoni CAA concentration at week 8, pg/ml | Continuous | Numeric | |
result_week8_caa | S. mansoni CAA result at week 8 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
caa_week28_caa | S. mansoni CAA concentration at week 28, pg/ml | Continuous | Numeric | |
result_week28_caa | S. mansoni CAA result at week 28 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
caa_week52_caa | S. mansoni CAA concentration at week 52, pg/ml | Continuous | Numeric | |
result_week52_caa | S. mansoni CAA result at week 52 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
necres_screen | Necator amerianus PCR result at screening | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
smres_screen | S. mansoni PCR result at screening | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
ssres_screen | Strongyloides stercoralis PCR result at screening | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
necres_wk28 | Necator amerianus PCR result at week 28 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
smres_wk28 | S. mansoni PCR result at week 28 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
ssres_wk28 | Strongyloides stercoralis PCR result at week 28 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
necres_wk52 | Necator amerianus PCR result at week 52 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | String | ||
smres_wk52 | S. mansoni PCR result at week 52 | |||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
ssres_wk52 | Strongyloides stercoralis PCR result at week 52 | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
pfal_res | Plasmodium falciparum PCR result at screening | String | ||
Positive | Pos | |||
Negative | Neg | |||
Indecisive | indecisive | |||
tt_IgG_week28 | Tetanus toxoid-specific IgG at week 28, IU/ml | Continuous | Numeric | |
dt_IgG_week28 | Diphtheria toxoid-specific IgG at week 28, IU/ml | Continuous | Numeric | |
tt_IgG_week52 | Tetanus toxoid-specific IgG at week 52, IU/ml | Continuous | Numeric | |
dt_IgG_week52 | Diphtheria toxoid-specific IgG at week 52, IU/ml | Continuous | Numeric | |
bcg_week0 | IFN-gamma response to BCG at week 0 (SFUs per million PBMCs) | Continuous | Numeric | |
bcg_week8 | IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) | Continuous | Numeric | |
bcg_week52 | IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) | Continuous | Numeric | |
yfprnt_50_wk0 | Yellow fever PRNT 50 titre at week 0 | Continuous | Numeric | |
yfprnt_90_wk0 | Yellow fever PRNT 90 titre at week 0 | Continuous | Numeric | |
yfprnt_50_wk8 | Yellow fever PRNT 50 titre at week 8 | Continuous | Numeric | |
yfprnt_90_wk8 | Yellow fever PRNT 90 titre at week 8 | Continuous | Numeric | |
yfprnt_50_wk52 | Yellow fever PRNT 50 titre at week 52 | Continuous | Numeric | |
yfprnt_90_wk52 | Yellow fever PRNT 90 titre at week 52 | Continuous | Numeric | |
typhi_igg_wk0 | S. typhi O:LPS-specific IgG at week 0, EU/ml | Continuous | Numeric | |
typhi_igg_wk8 | S. typhi O:LPS-specific IgG at week 8, EU/ml | Continuous | Numeric | |
typhi_igg_wk52 | S. typhi O:LPS-specific IgG at week 52, EU/ml | Continuous | Numeric | |
hpv16_wk0 | HPV-16-specific IgG concentration at week 0, EU/ml | Continuous | Numeric | |
hpv18_wk0 | HPV-18-specific IgG concentration at week 0, EU/ml | Continuous | Numeric | |
hpv16_wk8 | HPV-16-specific IgG concentration at week 8, EU/ml | Continuous | Numeric | |
hpv18_wk8 | HPV-18-specific IgG concentration at week 8, EU/ml | Continuous | Numeric | |
hpv16_wk52 | HPV-16-specific IgG concentration at week 52, EU/ml | Continuous | Numeric | |
hpv18_wk52 | HPV-18-specific IgG concentration at week 52, EU/ml | Continuous | Numeric |