Nkurunungi, G, Nassuuna, J, Natukunda, A, Zirimenya, L, Webb, E and Elliott, A. 2024. Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00003758.
Nkurunungi, G, Nassuuna, J, Natukunda, A, Zirimenya, L, Webb, E and Elliott, A. Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial" [Internet]. London School of Hygiene & Tropical Medicine; 2024. Available from: https://doi.org/10.17037/DATA.00003758.
Nkurunungi, G, Nassuuna, J, Natukunda, A, Zirimenya, L, Webb, E and Elliott, A (2024). Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00003758.
Description
This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was an open-label randomised controlled trial of intensive versus standard intervention against Schistosoma mansoni among schoolchildren (9-17 years) in Koome islands, Uganda (ISRCTN60517191).
The aim of the trial was to comprehensively address the hypothesis that Schistosoma mansoni infection causes suppression of responses to unrelated vaccines and that this effect can be reversed by intensive treatment with praziquantel.
The trial population was selected to comprise children at intense risk of exposure to Schistosoma mansoni infection in a “hot-spot”, island setting in Lake Victoria, Uganda.
A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of intensive treatment of Schistosoma mansoni on immune response to vaccines with different characteristics.
Additional information
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
Data capture method | Questionnaire, Lab observation | ||||
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Data Collection Period |
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Date (Date submitted to LSHTM repository) | 29 January 2024 | ||||
Language(s) of written materials | English |
Data Creators | Nkurunungi, G, Nassuuna, J, Natukunda, A, Zirimenya, L, Webb, E and Elliott, A |
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Associated roles | Zziwa, C (Researcher), Ninsiima, C (Researcher), Kabagenyi, J (Researcher), Kabuubi, P (Researcher), van Dam, G (Researcher), Corstjens, P (Researcher), Kayiwa, J (Researcher), Kizza, M (Researcher), Mutebe, A (Researcher), Nakazibwe, E (Researcher), Akello, F (Researcher), Sewankambo, M (Researcher), Kiwanuka, S (Researcher), Cose, S (Researcher), Wajja, A (Researcher) and Kaleebu, P (Researcher) |
LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
Participating Institutions | MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda, London School of Hygiene & Tropical Medicine, London, United Kingdom, Leiden University Medical Centre, Leiden, Netherlands |
Funders |
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Date Deposited | 02 Feb 2024 14:12 |
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Last Modified | 24 Oct 2024 13:02 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data / Code
Restricted to: Request access for all
Filename: POPVAC_A_data.txt
Description: POPVAC A dataset on helminths, trial intervention and vaccines
Licence: Data Sharing Agreement
Content type: Dataset
File size: 56B
Mime-Type: text/plain
Documentation
Filename: POPVAC_A_data_codebook.html
Description: POPVAC A data dictionary
Content type: Textual content
File size: 23kB
Mime-Type: text/html
Filename: 3758_UserGuide.html
Description: User guide for POPVAC A dataset
Content type: Textual content
File size: 8kB
Mime-Type: text/html