Gaskell, KM, El kheir, N, Mirfendesky, M, Rampling, T, Marks, M, Houlihan, CF, Lemonge, N, Bristowe, H, Aslam, S, Kyprianou, D, Nastouli, E, Goldblatt, D, Fielding, K and Moore, DAJ. 2023. S1 Data for: "Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study". [Online]. PLOS ONE. Available from: https://doi.org/10.1371/journal.pone.0284372.s003
Gaskell, KM, El kheir, N, Mirfendesky, M, Rampling, T, Marks, M, Houlihan, CF, Lemonge, N, Bristowe, H, Aslam, S, Kyprianou, D, Nastouli, E, Goldblatt, D, Fielding, K and Moore, DAJ. S1 Data for: "Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study" [Internet]. PLOS ONE; 2023. Available from: https://doi.org/10.1371/journal.pone.0284372.s003
Gaskell, KM, El kheir, N, Mirfendesky, M, Rampling, T, Marks, M, Houlihan, CF, Lemonge, N, Bristowe, H, Aslam, S, Kyprianou, D, Nastouli, E, Goldblatt, D, Fielding, K and Moore, DAJ (2023). S1 Data for: "Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study". [Data Collection]. PLOS ONE. https://doi.org/10.1371/journal.pone.0284372.s003
Description
Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and identifies only symptomatic contacts who are PCR positive at the time of sampling. We used serology to detect the relative transmissibility of Alpha Variant of Concern (VOC) to non-VOC SARS-CoV-2 to calculate household secondary attack rates. We identified index patients diagnosed with Alpha and non-VOC SARS-CoV-2 across two London Hospitals between November 2020 and January 2021 during a prolonged and well adhered national lockdown. We completed a household seroprevalence survey and found that 61.8% of non-VOC exposed household contacts were seropositive compared to 82.1% of Alpha exposed household contacts. The odds of infection doubled with exposure to an index diagnosed with Alpha. There was evidence of transmission events in almost all households. Our data strongly support that estimates of SAR should include serological data to improve accuracy and understanding.
| Data capture method | Questionnaire, Measurements and tests, Physical measurements and tests |
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| Date (Date published in a 3rd party system) | 24 April 2023 |
| Language(s) of written materials | English |
| Data Creators | Gaskell, KM, El kheir, N, Mirfendesky, M, Rampling, T, Marks, M, Houlihan, CF, Lemonge, N, Bristowe, H, Aslam, S, Kyprianou, D, Nastouli, E, Goldblatt, D, Fielding, K and Moore, DAJ |
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| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, North Middlesex University Hospital NHS Trust, London, United Kingdom, University College London Hospitals Foundation NHS Trust, London, United Kingdom, University College London, London, United Kingdom |
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| Date Deposited | 04 Jan 2024 12:56 |
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| Last Modified | 04 Jan 2024 16:53 |
| Publisher | PLOS ONE |
