Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data

Burke, R

(2024). Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.00003552.

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CASTLE is a cluster randomised trial comparing enhanced TB diagnostics (urine SILVAMP-LAM plus urine LF-LAM plus digital chest Xray with computer aided diagnosis plus usual care) to usual care alone, among adults living with HIV admitted to hospital. Clusters are day of admission to hospital. Primary outcome is TB treatment started prior to hospital discharge. Secondary outcomes are all-cause mortality at 56 days from enrolment, undiagnosed TB at time of discharge from hospital, and TB treatment initiation within 24 hours of enrolment. Data was collected using a combination of face-to-face questionnaire, laboratory test results, and information gathered from written medical records by trained research assistants.

Keywords

Tuberculosis; TB diagnostics; HIV

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Description of data capture	Data collected using a combination of face-to-face questionnaire, laboratory test results, and information gathered from written medical records by trained research assistants.
Capture method	Questionnaire, Aggregation, Physical measurements and tests
Collection Period	From To 5 September 2020 31 March 2022
Date	8 March 2024
Language(s) of written materials	English
Creator(s)	Burke, R
Associated roles	MacPherson, P (Co-Investigator) and Corbett, EL (Co-Investigator)
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	TB Centre
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi
Funders	Project Funder Grant Number Funder URI Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) Wellcome Trust 203905/Z/16/Z http://dx.doi.org/10.13039/100010269
Date Deposited	08 Mar 2024 11:35
Last Modified	19 Aug 2025 12:25
Publisher	London School of Hygiene & Tropical Medicine