Lazzarino, AI and Mindell, JS. 2017. Measuring high-sensitivity cardiac troponin T blood concentration in population surveys. [Online]. Figshare. Available from: https://doi.org/10.1371/journal.pone.0171242.s001
Lazzarino, AI and Mindell, JS. Measuring high-sensitivity cardiac troponin T blood concentration in population surveys [Internet]. Figshare; 2017. Available from: https://doi.org/10.1371/journal.pone.0171242.s001
Lazzarino, AI and Mindell, JS (2017). Measuring high-sensitivity cardiac troponin T blood concentration in population surveys. [Data Collection]. Figshare. https://doi.org/10.1371/journal.pone.0171242.s001
Description
The blood test for high-sensitivity cardiac troponin T (HS-CTnT) has been proposed as a marker of cardiovascular risk in the general population, as it is associated with subsequent incidence of cardiovascular events and mortality. We aimed at evaluating the feasibility of HS-CTnT testing within large nationally-representative population surveys in which blood samples are collected during household visits, shipped using the standard civil postal service, and then frozen for subsequent analyses. The Health Survey for England (HSE) consists of a series of annual surveys beginning in 1991. It is designed to provide regular information on various aspects of the nation's health and risk factors. We measured HS-CTnT in the blood of 200 people from the HSE 2016 wave, then froze and stored their blood samples at -40°C for 5-10 weeks, and then thawed and retested them to appreciate the extent of within-person agreement or test-retest reliability of the two measurements. The Cronbach's Alpha (Scale Reliability Coefficient) and the Interclass Correlation Coefficient (two-way mixed-effects model for consistency of agreement at individual level) were 0.97 (95%CI = 0.96-0.99) and 0.95 (95%CI = 0.94-0.96) respectively. The time delay from blood withdrawal to analysis and storage (1-4 days) did not affect the results, nor did the freezing time before the retest (5-10 weeks). The measurement of HS-CTnT plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.
Data capture method | Experiment: Laboratory |
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Date (Date published in a 3rd party system) | 31 January 2017 |
Language(s) of written materials | English |
Data Creators | Lazzarino, AI and Mindell, JS |
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LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, University College London, London, United Kingdom |
Date Deposited | 01 Mar 2017 14:54 |
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Last Modified | 15 Feb 2022 19:14 |
Publisher | Figshare |