Supplementary material from "A biphasic model of lifespan in nematode Caenorhabditis elegans worm"
Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial information on the mechanism of action. Here, we introduce a bilogistic model to describe the shape of the lifespan curves of Caenorhabditis elegans populations. Using the corrected Akaike information criterion and the RMSE as goodness-of-fit tests, we show that the bilogistic model provides a better fit to the experimental data from nematode worms than other mathematical models and can identify and confirm biphasic lifespan data. Our parametric model offers a method to interpret replicate experiments data in terms of the shape parameters of the lifespan curve and enables robust statistical analysis of intra- and inter-group variance. We apply the model to novel lifespan data from C. elegans and Drosophila melanogaster and provide a rational statistical analysis of lifespan modifiers such as temperature and daf-16/FOXO mutation.
Keywords
lifespan curve, mathematical modelling, Caenorhabditis elegans, Drosophila melanogasterItem Type | Dataset |
---|---|
Capture method | Other |
Date | 10 February 2023 |
Language(s) of written materials | English |
Creator(s) |
Mulla, S, Ludlam, AR, Elragig, A |
LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Funders |
Project Funder Grant Number Funder URI UNSPECIFIED EP/M02735X/1 http://dx.doi.org/10.13039/501100000266 |
Date Deposited | 02 Mar 2023 10:28 |
Last Modified | 02 Mar 2023 10:28 |
Publisher | Figshare |
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