Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Smith, A; Wall, RJ

; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE

; Thomas, MG

; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F

; Witty, MJ; Wyllie, S

; Read, KD

and Gilbert, IH

(2022). Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. [Dataset]. ACS Publications. https://doi.org/10.1021/acs.jmedchem.1c02104.s003

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Coordinates for the homology model of T. brucei CRK12 with compound 2 docked into the ATP site, as shown in Figure 5 within the article.

Keywords

Genetics; Infectious diseases; Livestock; Parasite; Rodent models

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Unknown
Date	18 March 2022
Language(s) of written materials	English
Creator(s)	Smith, A; Wall, RJ ; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE; Thomas, MG; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F; Witty, MJ; Wyllie, S ; Read, KD and Gilbert, IH
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology
Participating Institutions	University of Dundee, Dundee, United Kingdom; GALVmed, Edinburgh, United Kingdom; University of Basel, Basel, Switzerland; University of Greenwich, Chatham, United Kingdom; Centre International de Recherche-Développement sur l’Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso; London School of Hygiene and Tropical Medicine, London, United Kingdom
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Bill and Melinda Gates Foundation OPP1093639 http://dx.doi.org/10.13039/100000865 Project 202040 UK Aid UNSPECIFIED UNSPECIFIED Pathfinder Award Wellcome Trust 103127 http://dx.doi.org/10.13039/100010269 Wellcome Strategic Award to the Division of Biological Chemistry and Drug Discovery Wellcome Trust 100476 http://dx.doi.org/10.13039/100010269 Mode of Action group Wellcome Trust 105021 http://dx.doi.org/10.13039/100010269 Mode of Action group Wellcome Trust 218448 http://dx.doi.org/10.13039/100010269
Date Deposited	13 Jan 2023 15:24
Last Modified	09 Oct 2025 14:52
Publisher	ACS Publications