Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Smith, A; Wall, RJ
; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE; Thomas, MG; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F; Witty, MJ; Wyllie, S; Read, KD and Gilbert, IH
(2022).
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE; Thomas, MG; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F; Witty, MJ; Wyllie, S; Read, KD and Gilbert, IH
(2022).
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
Coordinates for the homology model of T. brucei CRK12 with compound 2 docked into the ATP site, as shown in Figure 5 within the article.
Keywords
Genetics; Infectious diseases; Livestock; Parasite; Rodent models| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Unknown |
| Date | 18 March 2022 |
| Language(s) of written materials | English |
| Creator(s) |
Smith, A; Wall, RJ; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE; Thomas, MG; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F; Witty, MJ; Wyllie, S; Read, KD and Gilbert, IH
|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Department of Infection Biology |
| Participating Institutions | University of Dundee, Dundee, United Kingdom; GALVmed, Edinburgh, United Kingdom; University of Basel, Basel, Switzerland; University of Greenwich, Chatham, United Kingdom; Centre International de Recherche-Développement sur l’Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso; London School of Hygiene and Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Wellcome Strategic Award to the Division of Biological Chemistry and Drug Discovery 100476 http://dx.doi.org/10.13039/100010269 |
| Date Deposited | 13 Jan 2023 15:24 |
| Last Modified | 09 Oct 2025 14:52 |
| Publisher | ACS Publications |
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