Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Smith, A, Wall, RJ, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH.
2022.
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Online].
ACS Publications.
Available from:
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
Smith, A, Wall, RJ, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH.
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
[Internet].
ACS Publications;
2022.
Available from:
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
Smith, A, Wall, RJ, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH
(2022).
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Data Collection].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
Description
Coordinates for the homology model of T. brucei CRK12 with compound 2 docked into the ATP site, as shown in Figure 5 within the article.
University of Dundee, Dundee, United Kingdom, GALVmed, Edinburgh, United Kingdom, University of Basel, Basel, Switzerland, University of Greenwich, Chatham, United Kingdom, Centre International de Recherche-Développement sur l’Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso, London School of Hygiene and Tropical Medicine, London, United Kingdom
