Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Smith, A, Wall, RJ
, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH
(2022).
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH
(2022).
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
[Dataset].
ACS Publications.
https://doi.org/10.1021/acs.jmedchem.1c02104.s003
Coordinates for the homology model of T. brucei CRK12 with compound 2 docked into the ATP site, as shown in Figure 5 within the article.
Keywords
Genetics, Infectious diseases, Livestock, Parasite, Rodent models| Item Type | Dataset |
|---|---|
| Capture method | Unknown |
| Date | 18 March 2022 |
| Language(s) of written materials | English |
| Creator(s) |
Smith, A, Wall, RJ, Patterson, S, Rowan, T, Rico Vidal, E, Stojanovski, L, Huggett, M, Hampton, SE, Thomas, MG, Corpas Lopez, V, Gillingwater, K, Duke, J, Napier, G, Peter, R, Vitouley, HS, Harrison, JR, Milne, R, Jeacock, L, Baker, N, Davis, SH, Simeons, F, Riley, J, Horn, D, Brun, R, Zuccotto, F, Witty, MJ, Wyllie, S, Read, KD and Gilbert, IH
|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Department of Infection Biology |
| Participating Institutions | University of Dundee, Dundee, United Kingdom, GALVmed, Edinburgh, United Kingdom, University of Basel, Basel, Switzerland, University of Greenwich, Chatham, United Kingdom, Centre International de Recherche-Développement sur l’Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso, London School of Hygiene and Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Wellcome Strategic Award to the Division of Biological Chemistry and Drug Discovery 100476 http://dx.doi.org/10.13039/100010269 |
| Date Deposited | 13 Jan 2023 15:24 |
| Last Modified | 13 Jan 2023 15:24 |
| Publisher | ACS Publications |
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