MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data

Aiken, A and Rehman, AM. 2023. MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00003168.

Aiken, A and Rehman, AM. MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data [Internet]. London School of Hygiene & Tropical Medicine; 2023. Available from: https://doi.org/10.17037/DATA.00003168.

Aiken, A and Rehman, AM (2023). MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00003168.

Description

Antimicrobial resistance is a major global health concern, but there is limited data linking laboratory resistance testing to clinical outcomes, especially from Low-and-Middle-Income countries, including African nations. This is a project collecting prospective data about bloodstream infections caused by Enterobacterales bacteria in African hospitals in 2020-22. A central focus was the impact of 3rd generation cephalosporin (3GC) resistance on patient mortality. In the main study, n=8 hospitals in eight different countries contributed to this project. Preliminary work involved collection of descriptive information from these 8 hospitals, including access to antibiotics in hospital pharmacies. Information was collected for infected patients and matched non-infected patients in same hospitals. The MBIRA study collected data about hospitals, patients, bacterial isolates and antibiotic use. The “mbira_hospital” dataset contains information collected as a one-off event as part of the “hospital” form and the “mbira_pharmacy” contains information on antibiotic availability in pharmacies that were collected each month. Further datasets will be made available at a later date.

Methods

Data capture method

Questionnaire

Data Collection Period

From	To
2 March 2020	31 March 2023

Date (Completed)

9 January 2023

Geographical area covered

North Latitude	East Longitude	South Latitude	West Longitude
15.2743	54.4812	-35.3974	-23.5657

Language(s) of written materials

English

People & Groups

Data Creators	Aiken, A and Rehman, AM
Associated roles	Rehman, AM (Co-Investigator)
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023)
Research Centre	Antimicrobial Resistance Centre (AMR)
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, Stellenbosch University, South Africa, KEMRI-Wellcome Trust, Kenya, University of Ghana Medical School, Ghana, Centre for Infectious Diseases Research in Zambia, Zambia, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Malawi, Haramaya University, Ethiopia, National Hospital Abuja, Nigeria

Projects

Funders

Project	Funder	Grant Number	Funder URI
Mortality from Bacterial Infections Resistant to Antibiotics (MBIRA)	Bill and Melinda Gates Foundation	INV-003519	http://dx.doi.org/10.13039/100000865

Additional Information

Date Deposited	09 Jan 2023 15:26
Last Modified	23 Jun 2023 11:29
Publisher	London School of Hygiene & Tropical Medicine

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Data / Code

mbira_hospital_data Download

Filename: mbira_hospital_data.xlsx

Description: Data collected as part of a cross-sectional survey in hospitals conducted at the start of the MBIRA study

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Content type: Dataset

File size: 13kB

Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

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MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data

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mbira_hospital_data Download

mbira_pharmacy_v2 Download

mbira_data Request access

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MBIRA_data_documentation_appendices Download

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Study Instrument

MBIRA_patient information_child_English Download

External resources

MBIRA study (Project)

Associated papers in Research Online

Mortality attributable to third-generation cephalosporin resistance in Gram-negative bloodstream infections in African hospitals: a multi-site...

Mortality associated with third-generation cephalosporin resistance in Enterobacteriaceae bloodstream infections at one South African hospital.

Circumstances for treatment and control of invasive Enterobacterales infections in eight hospitals across sub-Saharan Africa: a cross-sectional study

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MBIRA - Mortality from Bacterial Infections Resistant to Antibiotics study - underlying data

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Documentation

Study Instrument

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Associated papers in Research Online

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