Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT)

Wang, SV, Sreedhara, SK, Schneeweiss, S, Franklin, JM, Gagne, JJ, Huybrechts, KF, Patorno, E, Jin, Y, Lee, M, Mahesri, M, Pawar, A, Barberio, J, Bessette, LG, Chin, K, Gautam, N, Ortiz, AS, Sears, E, Stefanini, K, Zakarian, M, Dejene, S, Rogers, JR, Brill, G, Landon, J, Lii, J, Tsacogianis, T, Vine, S, Garry, EM, Gibbs, LR, Gierada, M, Isaman, DL, Payne, E, Alwardt, S, Arlett, P, Bartels, DB, Bate, A, Berlin, J, Bourke, A, Bradbury, B, Brown, J, Burnett, K, Brennan, T, Chan, KA, Choi, N, de Vries, F, Eichler, H, Filion, KB, Freeman, L, Hallas, J, Happe, L, Hennessy, S, Jónsson, P, Ioannidis, J, Jimenez, J, Kahler, KH, Laine, C, Loder, E, Makady, A, Martin, D, Nguyen, M, Nosek, B, Platt, R, Platt, RW, Seeger, J, Shrank, W, Smeeth, LORCID logo, Sørensen, HT, Tugwell, P, Uyama, Y, Willke, R, Winkelmayer, W and Zarin, D (2022). Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT). [Dataset]. OSF. https://doi.org/10.17605/OSF.IO/MY5GN
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Studies that generate real-world evidence (RWE) through analysis of routinely collected healthcare data provide key insights for regulators, payers, and other healthcare decision-makers. In this project, we evaluated clarity of methodology reporting for 250 RWE studies and attempted to reproduce 150 studies using the same data sources and methods reported by the original investigators.

Keywords

Outcomes research, Reproducibility, Routinely collected healthcare data


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