Salgueiro, P, Lopes, AS, Mendes, C, Charlwood, JD, Arez, AP, Pinto, J and Silveira, H. 2016. Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato). [Online]. Parasites & Vectors. Available from: https://doi.org/10.1186/s13071-016-1800-2.
Salgueiro, P, Lopes, AS, Mendes, C, Charlwood, JD, Arez, AP, Pinto, J and Silveira, H. Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato). [Internet] LSHTM Data Compass. Parasites & Vectors; 2016. Available from: https://doi.org/10.1186/s13071-016-1800-2.
Salgueiro, P, Lopes, AS, Mendes, C, Charlwood, JD, Arez, AP, Pinto, J and Silveira, H (2016). Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato). [Data Collection]. Parasites & Vectors. https://doi.org/10.1186/s13071-016-1800-2.
Description
Clarifying the role of the innate immune system of the malaria vector Anopheles gambiae is a potential way to block the development of the Plasmodium parasites. Pathogen recognition is the first step of innate immune response, where pattern recognition proteins like GNBPs play a central role. We analysed 70 sequences of the protein coding gene GNBPB2 from two species, Anopheles gambiae (s.s.) and An. coluzzii, collected in six African countries. We detected 135 segregating sites defining 63 distinct haplotypes and 30 proteins. Mean nucleotide diversity (π) was 0.014 for both species. We found no significant genetic differentiation between species, but a significant positive correlation between genetic differentiation and geographical distance among populations. Species status seems to contribute less for the molecular differentiation in GNBPB2 than geographical region in the African continent (West and East). Purifying selection was found to be the most common form of selection, as in many other immunity-related genes. Diversifying selection may be also operating in the GNBPB2 gene.
| Data capture method | Experiment |
|---|---|
| Date (Published in a 3rd party system) | 23 September 2016 |
| Language(s) of written materials | English |
| Data Creators | Salgueiro, P, Lopes, AS, Mendes, C, Charlwood, JD, Arez, AP, Pinto, J and Silveira, H |
|---|---|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Participating Institutions | Global Health and Tropical Medicine Centre (GHTM), Unidade de Parasitologia Médica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa, London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Depositor | Gareth Knight |
|---|---|
| Date Deposited | 11 Oct 2016 10:19 |
| Last Modified | 16 Jan 2019 21:59 |
| Publisher | Parasites & Vectors |
