Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial”
Glynn, JR
, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P
(2021).
Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial”.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00002443.
, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P
(2021).
Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial”.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00002443.
Individual level data on vaccine allocation and outcome (leprosy and tuberculosis incidence) on more than 120,000 recruited into the vaccine trial in 1986-89 and followed up until December 2018.
Additional Information
This data submission is currently being prepared - August 2021
Keywords
BCG, BCG revaccination, Vaccine trial, Tuberculosis, Leprosy, BCG + killed M leprae vaccine, Bacillus Calmette-Guérin| Item Type | Dataset |
|---|---|
| Description of data capture | Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Those without a BCG scar were randomised to receive BGG or a combined BCG + killed M leprae vaccine. Surveillance was by a mixture of active and passive surveillance. The original trial methods and results after 5-9 years follow-up are described in detail in: [1] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [2] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. |
| Capture method | Questionnaire: Fixed form - Paper, Measurements and tests |
| Collection Period |
From To January 1986 December 2018 |
| Date | 12 August 2021 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -9.91763 33.938 -10.0123 33.8817 |
| Language(s) of written materials | English |
| Creator(s) |
Glynn, JR, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P
|
| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) |
| Research Group | MEIRU (Malawi Epidemiology and Intervention Research Unit) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, MEIRU (Malawi Epidemiology and Intervention Research Unit) |
| Funders |
Project Funder Grant Number Funder URI Karonga Prevention Trial UNSPECIFIED UNSPECIFIED Karonga Prevention Trial UNSPECIFIED UNSPECIFIED Karonga Prevention Trial 063558/01, 079827/06, 098610/12 http://dx.doi.org/10.13039/100010269 Karonga Prevention Trial OPP1210686 http://dx.doi.org/10.13039/100000865 |
| Date Deposited | 12 Aug 2021 11:43 |
| Last Modified | 01 Feb 2022 17:47 |
| Publisher | London School of Hygiene & Tropical Medicine |
Explore Further
- Glynn, Judith
- Fielding, Katherine
- Mzembe, Themba
- Mclean, Estelle
- Kanjala, Chifundo
- Crampin, Amelia C.
- Fine, Paul
BCG_revaccination_dataset.txt
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subject - Data
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lock - Restricted to Request access for all
- Data Sharing Agreement
- Available under Data Sharing Agreement
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info - BCG Revaccination dataset
description - text/plain
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2443-UserGuide.html
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subject - Documentation
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
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info - User guide for BCG Revaccination dataset
html - text/html
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