Glynn, JR, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P. 2021. Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial”. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00002443.
Glynn, JR, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P. Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial” [Internet]. London School of Hygiene & Tropical Medicine; 2021. Available from: https://doi.org/10.17037/DATA.00002443.
Glynn, JR, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P (2021). Data for: “BCG revaccination in Malawi: 30-year follow-up of a large, randomised, double-blind placebo-controlled trial”. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00002443.
Description
Individual level data on vaccine allocation and outcome (leprosy and tuberculosis incidence) on more than 120,000 recruited into the vaccine trial in 1986-89 and followed up until December 2018.
Additional information
This data submission is currently being prepared - August 2021
Description of data capture | Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Those without a BCG scar were randomised to receive BGG or a combined BCG + killed M leprae vaccine. Surveillance was by a mixture of active and passive surveillance. The original trial methods and results after 5-9 years follow-up are described in detail in: [1] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [2] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. | ||||||||
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Data capture method | Questionnaire: Fixed form - Paper, Measurements and tests | ||||||||
Data Collection Period |
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Date (Date submitted to LSHTM repository) | 12 August 2021 | ||||||||
Geographical area covered (offline during plugin upgrade) |
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Language(s) of written materials | English |
Data Creators | Glynn, JR, Fielding, K, Mzembe, T, Sichali, L, Banda, L, Mclean, E, Kanjala, C, Crampin, AC, Ponnighaus, J, Warndorff, D and Fine, P |
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LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
Research Group | MEIRU (Malawi Epidemiology and Intervention Research Unit) |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, MEIRU (Malawi Epidemiology and Intervention Research Unit) |
Funders |
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Date Deposited | 12 Aug 2021 11:43 |
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Last Modified | 01 Feb 2022 17:47 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data / Code
Restricted to: Request access for all
Filename: BCG_revaccination_dataset.txt
Description: BCG Revaccination dataset
Licence: Data Sharing Agreement
Content type: Dataset
File size: 54B
Mime-Type: text/plain
Documentation
Filename: 2443-UserGuide.html
Description: User guide for BCG Revaccination dataset
Content type: Textual content
File size: 6kB
Mime-Type: text/html