Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

Milligan, P. 2021. Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00002136.

Milligan, P. Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study [Internet]. London School of Hygiene & Tropical Medicine; 2021. Available from: https://doi.org/10.17037/DATA.00002136.

Milligan, P (2021). Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00002136.

Description

Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in the Sahel (ACCESS-SMC) project sought to remove barriers to the scale-up of SMC in seven countries in 2015 and 2016. We evaluated the project, including coverage, effectiveness of the intervention, safety, feasibility, drug resistance, and cost-effectiveness. For this observational study, we collected data on the delivery, effectiveness, safety, influence on drug resistance, costs of delivery, impact on malaria incidence and mortality, and cost-effectiveness of SMC, during its administration for 4 months each year (2015 and 2016) to children younger than 5 years, in Burkina Faso, Chad, The Gambia, Guinea, Mali, Republic of the Niger, and Nigeria. SMC was administered monthly by community health workers who visited door-to-door. Drug administration was monitored via tally sheets and via household cluster-sample coverage surveys. Pharmacovigilance was based on targeted spontaneous reporting and monitoring systems were strengthened. Molecular markers of resistance to sulfadoxine–pyrimethamine and amodiaquine in the general population before and 2 years after SMC introduction was assessed from community surveys. Effectiveness of monthly SMC treatments was measured in case-control studies that compared receipt of SMC between patients with confirmed malaria and neighbourhood-matched community controls eligible to receive SMC. Impact on incidence and mortality was assessed from confirmed outpatient cases, hospital admissions, and deaths associated with malaria, as reported in national health management information systems in Burkina Faso and The Gambia, and from data from selected outpatient facilities (all countries). Provider costs of SMC were estimated from financial costs, costs of health-care staff time, and volunteer opportunity costs, and cost-effectiveness ratios were calculated as the total cost of SMC in each country divided by the predicted number of cases averted. This collection contains data collected as part of the SMC coverage surveys, case control studies, malaria incidence at health facilities, and molecular markers of resistance, as well as the accompanying protocols, reports, and tools produced by the Access-SMC study. Please consult the file listing for further information.

Methods

Description of data capture

Coverage surveys: household survey questionnaires Case control studies: questionnaires Molecular marker surveys: survey questionnaires and lab data Impact: health facility data on confirmed malaria cases from clinic registers

Data capture method

Questionnaire

Data Collection Period

From	To
1 January 2014	31 May 2021

Date (Date submitted to LSHTM repository)

25 March 2021

Language(s) of written materials

English, French

People & Groups

Data Creators	Milligan, P
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre	Malaria Centre
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, Malaria Consortium, Catholic Relief Services, United States, Medicines for Malaria Venture, Geneva, Switzerland, Speak Up Africa, Management Sciences for Health

Projects

Funders

Project	Funder	Grant Number	Funder URI
ACCESS-SMC	UNITAID	UNSPECIFIED	https://unitaid.org/#en

Additional Information

Date Deposited	10 Sep 2021 10:13
Last Modified	13 Sep 2021 16:36
Publisher	London School of Hygiene & Tropical Medicine

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Data / Code

Access-SMC-datasets Request access

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Filename: Access-SMC-datasets.zip

Description: Data on coverage, efficacy, resistance and impact from the ACCESS-SMC evaluation. Please contact study team directly to discuss datasets

Licence: Data Sharing Agreement

Content type: Dataset

File size: 231B

Mime-Type: application/zip

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Documentation

SMC_Evaluation_Protocol Request access

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Filename: SMC_Evaluation_Protocol.pdf

Description: ACCESS-SMC Evaluation Protocol v1.6 (June 2021)

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File size: 1MB

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SMC_Coverage_Report Request access

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Filename: SMC_Coverage_Report.pdf

Description: ACCESS-SMC evaluation final report: Seasonal malaria chemoprevention coverage in seven West African countries, 2015-2016 (June 2018)

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File size: 2MB

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SMC_DrugResistance_Baseline_Report Request access

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Filename: SMC_DrugResistance_Baseline_Report.pdf

Description: ACCESS-SMC Evaluation: Assessment of the frequency of molecular markers associated with resistance to SP+AQ in seven countries before scaling up of seasonal malaria chemoprevention

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File size: 1MB

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SMC_DrugResistance_Survey_Report Request access

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Filename: SMC_DrugResistance_Survey_Report.pdf

Description: ACCESS-SMC Drug Resistance Survey Report: Assessment of the frequency of molecular markers associated with resistance to SMC drugs in 7 countries after two years of SMC at scale (Feb 10 2020)

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Content type: Textual content

File size: 569kB

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SMC_Efficacy_Report Request access

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Filename: SMC_Efficacy_Report.pdf

Description: ACCESS-SMC evaluation: Assessment of the protective efficacy of Seasonal Malaria Chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine in Burkina Faso, Chad, The Gambia, Mali and Nigeria, 2015-2016

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Content type: Textual content

File size: 874kB

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SMC_Impact_Report Request access

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Filename: SMC_Impact_Report.pdf

Description: ACCESS-SMC evaluation: Assessment of the impact of ACCESS-SMC on malaria cases and deaths in 2015 and 2016

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File size: 3MB

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SMC_Safety_Monitoring_Report Request access

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Filename: SMC_Safety_Monitoring_Report.pdf

Description: ACCESS-SMC evaluation: Monitoring the safety of Seasonal Malaria Chemoprevention during large scale implementation through the ACCESS-SMC project 2015-16

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File size: 2MB

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2136-UserGuide Download

Filename: 2136-UserGuide.html

Description: User guide for the collection

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Study Instrument

Access-SMC-Tools Request access

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Filename: Access-SMC-Tools.zip

Description: Zip file that contains job aids for Pharmacovigilance, Open Data Kit questionnaire for coverage surveys (v0.5), and the Standard Operating Procedures (SOP) for the SMC case control studies

Licence: Data Sharing Agreement

Content type: Textual content

File size: 1MB

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Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

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