Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study – User Guide

Permanent identifier

https://doi.org/10.17037/DATA.00002136

File description

This collection contains data collected as part of the SMC coverage surveys, case control studies, malaria incidence at health facilities, and molecular markers of resistance, as well as the accompanying protocols, reports, and tools produced by the Access-SMC study. Please consult the file listing for further information.

Study description

Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in the Sahel (ACCESS-SMC) project sought to remove barriers to the scale-up of SMC in seven countries in 2015 and 2016. We evaluated the project, including coverage, effectiveness of the intervention, safety, feasibility, drug resistance, and cost-effectiveness. For this observational study, we collected data on the delivery, effectiveness, safety, influence on drug resistance, costs of delivery, impact on malaria incidence and mortality, and cost-effectiveness of SMC, during its administration for 4 months each year (2015 and 2016) to children younger than 5 years, in Burkina Faso, Chad, The Gambia, Guinea, Mali, Republic of the Niger, and Nigeria. SMC was administered monthly by community health workers who visited door-to-door. Drug administration was monitored via tally sheets and via household cluster-sample coverage surveys. Pharmacovigilance was based on targeted spontaneous reporting and monitoring systems were strengthened. Molecular markers of resistance to sulfadoxine–pyrimethamine and amodiaquine in the general population before and 2 years after SMC introduction was assessed from community surveys. Effectiveness of monthly SMC treatments was measured in case-control studies that compared receipt of SMC between patients with confirmed malaria and neighbourhood-matched community controls eligible to receive SMC. Impact on incidence and mortality was assessed from confirmed outpatient cases, hospital admissions, and deaths associated with malaria, as reported in national health management information systems in Burkina Faso and The Gambia, and from data from selected outpatient facilities (all countries). Provider costs of SMC were estimated from financial costs, costs of health-care staff time, and volunteer opportunity costs, and cost-effectiveness ratios were calculated as the total cost of SMC in each country divided by the predicted number of cases averted.

Description of data capture

Coverage surveys: household survey questionnaires Case control studies: questionnaires Molecular marker surveys: survey questionnaires and lab data Impact: health facility data on confirmed malaria cases from clinic registers.

Keywords

Seasonal Malaria Chemoprevention, Sahel, ACCESS-SMC

Date

The research study took place between 1 January 2014 - 31 May 2021

Survey work was undertaken during 2015 and 2016. Please consult project documentation (listed below) for information on specific survey work.

Files were submitted to the LSHTM repository on 25 March 2021.

Participating Institutions

The following organisations collaborated on the study:

• London School of Hygiene & Tropical Medicine, London, United Kingdom
• Malaria Consortium
• Catholic Relief Services, United States
• Medicines for Malaria Venture, Geneva, Switzerland
• Speak Up Africa
• Management Sciences for Health

Project Information

Publications associated with this item

• ACCESS-SMC Partnership; (2020) Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study. The Lancet, 396 (10265). pp. 1829-1840. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(20)32227-3

• Cairns, M., Ceesay, S., Sagara, I., Zongo, I., Kessely, H., Gamougam, K., Diallo, A., Ogboi, J., Moroso, D., Van Hulle, S., Eloike, T., Snell, P., Scott, S., Merle, C., Bojang, K., Ouedraogo, J., Dicko, A., Ndiaye, J. and Milligan, P., 2021. Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case–control studies in 5 countries. PLOS Medicine, 18(9), p.e1003727. DOI: https://doi.org/10.1371/journal.pmed.1003727

• Gilmartin, Colin; Nonvignon, Justice; Cairns, Matthew; Milligan, Paul; Bocoum, Fadima; Winskill, Peter; Moroso, Diego; Collins, David; (2021) Seasonal malaria chemoprevention in the Sahel subregion of Africa: a cost-effectiveness and cost-savings analysis. The Lancet Global Health, 9 (2). e199-e208. DOI: https://doi.org/10.1016/S2214-109X(20)30475-7

File description

ACCESS-SMC Evaluation Reports

ACCESS-SMC Protocol

ACCESS-SMC Tools

ACCESS-SMC Datasets

The following datasets were collected by the ACCESS-SMC research team for analysis within the study. They are held in the LSHTM repository for preservation purposes only. Please contact the study team directly to discuss datasets produced in the study.