MOESM4 of Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

Ochola-Oyier, LI, Okombo, J, Wagatua, N, Ochieng, J, Tetteh, KKORCID logo, Fegan, G, Bejon, P and Marsh, K (2016). MOESM4 of Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population. [Dataset]. Figshare. https://doi.org/10.6084/m9.figshare.c.3603686_D5.v1
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Linkage disequilibrium (LD) analysis of all high frequency (>5%) SNPs in all 15 merozoite genes, except eba181 due to limited SNP data. The analysis was performed by conducting all possible pair-wise comparisons between all the SNPs across 14 merozoite genes using a pair-wise correlation analysis and a Bonferroni correction for multiple comparisons. The red boxes represent significant correlations between SNPs and thus SNPs in LD, orange represents correlations between SNPs that are not significant, white indicates the SNPs that are not correlated and therefore they are not in LD and grey represents cases where the SNP data is missing in one or both of the paired SNPs.

Keywords

Rh5, Merozoite, Plasmodium, Malaria

File1-PCRconditions_and_PrimerSequences.xlsx
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PCR conditions and primer sequences for the gene regions analysed in the 15 merozoite genes
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File2-Merozoite_gene.docx
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Merozoite gene allele frequencies in the uncomplicated malaria infections between 2007 and 2008
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File3-genotypeParasitePairs.docx
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The proportion of same and different genotype parasite pairs in vivo and in vitro
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File4-LD_analysis.xlsx
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Linkage disequilibrium (LD) analysis of all high frequency (>5%) SNPs in all 15 merozoite genes, except eba181 due to limited SNP data
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File5-SNPs_RepeatRegionFrequencies.xlsx
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SNPs and repeat region frequencies within the 15 merozoite genes from the uncomplicated malaria infections in 2007 and 2008 to identify significant SNPs
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File6_Rh5_SNPs.docx
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Rh5 SNPs in 11 geographically distinct laboratory isolates
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