Mansour, NR, Paveley, R, Gardner, JMF, Bell, AS, Parkinson, T and Bickle, Q. 2016. High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni. [Online]. Figshare. Available from: https://doi.org/10.1371/journal.pntd.0004659.
Mansour, NR, Paveley, R, Gardner, JMF, Bell, AS, Parkinson, T and Bickle, Q. High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni [Internet]. Figshare; 2016. Available from: https://doi.org/10.1371/journal.pntd.0004659.
Mansour, NR, Paveley, R, Gardner, JMF, Bell, AS, Parkinson, T and Bickle, Q (2016). High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni. [Data Collection]. Figshare. https://doi.org/10.1371/journal.pntd.0004659.
Description
An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization.
Data capture method | Experiment |
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Date (Published in a 3rd party system) | 29 April 2016 |
Language(s) of written materials | English |
Data Creators | Mansour, NR, Paveley, R, Gardner, JMF, Bell, AS, Parkinson, T and Bickle, Q |
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LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection |
Participating Institutions | Study consortium |
Funders |
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Date Deposited | 04 May 2016 10:47 |
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Last Modified | 27 Apr 2022 18:20 |
Publisher | Figshare |
Downloads
Data / Code
Filename: S1_Additional_Actives_Table.XLSX
Description: Table of additional actives obtained during the screening. These structures were deprioritised relative to those in the body of the paper for the reasons given in the comment column. The assays are those described in the paper. ND = No data obtained.
Content type: Dataset
File size: 105kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S2_StructuresTable.XLSX
Description: A list of structures described in the paper and a summary of findings obtained using the KNIME workflow ‘Know Your Molecule’ to access and present ChemBl data. The structures shown are those similar to the compound number listed in column 1 of the table
Content type: Dataset
File size: 248kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet