Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study data set

Gupta-Wright, A (2020). Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study data set. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.00001824.
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This dataset contains information collected as part of a cohort study to investigate ART failure, drug resistance, and early mortality among patients with HIV admitted to hospital in Malawi. The observational cohort study was nested within the rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalised patients in Africa (STAMP) trial, which recruited unselected (i.e. irrespective of clinical presentation), adult (aged ≥18 years) patients with HIV-1 at admission to medical wards. Patients were included in our observational cohort study if they were enrolled at the Malawi site (Zomba Central Hospital) and were taking ART for at least 6 months at admission. Patients who met inclusion criteria had frozen plasma samples tested for HIV-1 viral load. Those with HIV-1 RNA of at least 1000 copies per mL had drug resistance testing by ultra-deep sequencing, with drug resistance defined as intermediate or high-level resistance using the Stanford HIVDR program. Mortality risk was calculated 56 days from enrolment. Patients were censored at death, at 56 days, or at last contact if lost to follow-up. The modelling strategy addressed the causal association between HIV multidrug resistance and mortality, excluding factors on the causal pathway (most notably, CD4 cell count, clinical signs of advanced HIV, and poor functional and nutritional status).

Additional Information

Dataset in preparation. Please contact data creator directly.

Keywords

HIV, Virological failure, Drug resistance, Human Immunodeficiency Virus

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