Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT. 2016. A Metabolic Study of Huntington’s Disease. [Online]. PLOS One. Available from: https://doi.org/10.1371/journal.pone.0146480
Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT. A Metabolic Study of Huntington’s Disease [Internet]. PLOS One; 2016. Available from: https://doi.org/10.1371/journal.pone.0146480
Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT (2016). A Metabolic Study of Huntington’s Disease. [Data Collection]. PLOS One. https://doi.org/10.1371/journal.pone.0146480
Description
Data produced as part of a study of metabolic factors in Huntington’s disease gene carriers. The study sought to determine whether various metabolic variables are linked to disease state in a cross-sectional study of cohorts of HD gene carriers and controls. The study team examined carbohydrate, lipid and protein metabolites as well as hormones related to energy metabolism in plasma samples from well-characterised cohorts of premanifest and moderate HD subjects and healthy controls.
Keywords
| Description of data capture | Control (n = 15), premanifest (n = 14) and stage II/III (n = 13) participants were studied with blood sampling over a 24-hour period. A battery of clinical tests including neurological rating and function scales were performed. Visceral and subcutaneous adipose distribution was measured using magnetic resonance imaging. We quantified fasting baseline concentrations of glucose, insulin, cholesterol, triglycerides, lipoprotein (a), fatty acids, amino acids, lactate and osteokines. Leptin and ghrelin were quantified in fasting samples and after a standardised meal. We assessed glucose, insulin, growth hormone and cortisol concentrations during a prolonged oral glucose tolerance test. |
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| Data capture method | Experiment |
| Date (Date published in a 3rd party system) | 8 January 2016 |
| Language(s) of written materials | English |
| Data Creators | Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT |
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| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Medical Statistics |
| Participating Institutions | London School of Hygiene & Tropical Medicine, University College London, Lund University, Necker Hospital, University of Oxford, Royal Free London NHS Foundation Trust, Fondazione CNR-Regione Toscana G, Imperial College |
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| Date Deposited | 14 Jan 2016 10:36 |
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| Last Modified | 08 Jul 2021 12:48 |
| Publisher | PLOS One |
