Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
Penn-Nicholson, A; Hraha, T; Thompson, EG; Sterling, D; Kimbung Mbandi, S; Wall, K; Fisher, M; Suliman, S; Shankar, S; Hanekom, WA; Janjic, N; Hatherill, M; Kaufmann, SH; Sutherland, J
; Walzl, G; De Groote, MA and Ochsner, U
(2019).
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
[Dataset].
PLOS Medicine.
https://doi.org/10.1371/journal.pmed.1002781.s007
; Walzl, G; De Groote, MA and Ochsner, U
(2019).
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
[Dataset].
PLOS Medicine.
https://doi.org/10.1371/journal.pmed.1002781.s007
A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care diagnostic.
Keywords
findings Proteomic TB risk signatures; TB disease; prognostic proteomic signature; Prognostic performance; 3 PR signature| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment |
| Date | 16 April 2019 |
| Language(s) of written materials | English |
| Creator(s) |
Penn-Nicholson, A; Hraha, T; Thompson, EG; Sterling, D; Kimbung Mbandi, S; Wall, K; Fisher, M; Suliman, S; Shankar, S; Hanekom, WA; Janjic, N; Hatherill, M; Kaufmann, SH; Sutherland, J; Walzl, G; De Groote, MA and Ochsner, U
|
| LSHTM Faculty/Department | MRC Unit The Gambia at LSHTM |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 24 Jul 2019 10:12 |
| Last Modified | 26 Jun 2025 11:12 |
| Publisher | PLOS Medicine |
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