Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

Penn-Nicholson, A, Hraha, T, Thompson, EG, Sterling, D, Kimbung Mbandi, S, Wall, K, Fisher, M, Suliman, S, Shankar, S, Hanekom, WA, Janjic, N, Hatherill, M, Kaufmann, SH, Sutherland, J

, Walzl, G, De Groote, MA and Ochsner, U (2019). Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study. [Dataset]. PLOS Medicine. https://doi.org/10.1371/journal.pmed.1002781.s007

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A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care diagnostic.

Keywords

findings Proteomic TB risk signatures, TB disease, prognostic proteomic signature, Prognostic performance, 3 PR signature

Item Type	Dataset
Capture method	Experiment
Date	16 April 2019
Language(s) of written materials	English
Creator(s)	Penn-Nicholson, A, Hraha, T, Thompson, EG, Sterling, D, Kimbung Mbandi, S, Wall, K, Fisher, M, Suliman, S, Shankar, S, Hanekom, WA, Janjic, N, Hatherill, M, Kaufmann, SH, Sutherland, J , Walzl, G, De Groote, MA and Ochsner, U
LSHTM Faculty/Department	MRC Unit The Gambia at LSHTM
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Bill and Melinda Gates Foundation OPP1091720 http://dx.doi.org/10.13039/100000865 UNSPECIFIED Bill and Melinda Gates Foundation OPP1023483 http://dx.doi.org/10.13039/100000865 UNSPECIFIED Bill and Melinda Gates Foundation OPP1065330 http://dx.doi.org/10.13039/100000865 UNSPECIFIED Bill and Melinda Gates Foundation OPP1065330 http://dx.doi.org/10.13039/100000865
Date Deposited	24 Jul 2019 10:12
Last Modified	26 Jun 2025 11:12
Publisher	PLOS Medicine