Additional file 1: of A genomic atlas of systemic interindividual epigenetic variation in humans

Gunasekara, CJ; Scott, CA; Laritsky, E; Baker, MS; MacKay, H; Duryea, JD; Kessler, NJ

; Hellenthal, H; Wood, AC; Hodges, KR; Gandhi, M; Hair, AB; Silver, M

; Li, Y; Chen, R; Coarfa, C and Waterland, RA (2019). Additional file 1: of A genomic atlas of systemic interindividual epigenetic variation in humans. [Dataset]. Figshare. https://doi.org/10.6084/m9.figshare.8217572.v1

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DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in DNA methylation occurs systemically. Like genetic variants, systemic interindividual epigenetic variants are stable, can influence phenotype, and can be assessed in any easily biopsiable DNA sample. We describe an unbiased screen for human genomic regions at which interindividual variation in DNA methylation is not tissue-specific.

Keywords

Supplementary; genomic atlas; variation; Additional; interindividual

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Experiment
Date	3 June 2019
Language(s) of written materials	English
Creator(s)	Gunasekara, CJ; Scott, CA; Laritsky, E; Baker, MS; MacKay, H; Duryea, JD; Kessler, NJ ; Hellenthal, H; Wood, AC; Hodges, KR; Gandhi, M; Hair, AB; Silver, M ; Moore, SE; Prentice, AM ; Li, Y; Chen, R; Coarfa, C and Waterland, RA
LSHTM Faculty/Department	MRC Unit The Gambia at LSHTM
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Bill and Melinda Gates Foundation UNSPECIFIED http://dx.doi.org/10.13039/100000865 UNSPECIFIED National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK111522 http://dx.doi.org/10.13039/100000062 UNSPECIFIED Cancer Prevention and Research Institute of Texas RP170295 UNSPECIFIED
Date Deposited	22 Jul 2019 13:25
Last Modified	03 Feb 2026 11:14
Publisher	Figshare