Cross-transmission is not the source of new Mycobacterium abscessus infections in a multi-centre cohort of cystic fibrosis patients

Doyle, RMORCID logo, Rubio, M, Dixon, G, Hartley, J, Klein, N, Coll, P and Harris, KA (2019). Cross-transmission is not the source of new Mycobacterium abscessus infections in a multi-centre cohort of cystic fibrosis patients. [Dataset]. Clinical Infectious Diseases. https://doi.org/10.1101/582684 https://doi.org/10.1093/cid/ciz526
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Mycobacterium abscessus is an extensively drug resistant pathogen that causes pulmonary disease particularly in cystic fibrosis (CF) patients. Identifying direct patient-to-patient transmission of M. abscessus is critically important in directing infection control policy for the management of risk in CF patients. A variety of clinical labs have used molecular epidemiology to investigate transmission. However there is still conflicting evidence as to how M. abscessus is acquired and whether cross-transmission occurs. Recently labs have applied whole-genome sequencing (WGS) to investigate this further and in this study we investigate whether WGS can reliably identify cross-transmission in M. abscessus.

Keywords

Mycobacterium abscessus, Cross-transmission, cystic fibrosis

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