The conjunctival transcriptome in scarring trachoma for Tanzanians
; Hu, V; Bauer, J; Mabey, D; Holland, MJ and Bailey, RL
(2011).
The conjunctival transcriptome in scarring trachoma for Tanzanians.
[Dataset].
NCBI Gene Expression Omnibus.
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24383
Trachoma is a poorly understood immuno-fibrogenic disease process, initiated by Chlamydia trachomatis (Ct). Differences in conjunctival gene expression profiles between Tanzanians with trachomatous conjunctival scarring (with (TSI) and without (TS) inflammation) and controls (C) were investigated to identify relevant host responses. Tarsal conjunctival swab samples were collected for RNA isolation and Ct PCR. Transcriptome-wide microarray experiments were conducted on 41 samples (TSI 13, TS 15, C14). Cases had enrichment in proinflammatory cytokines and chemokines (IL1B, IL8, CXCL5, CCL20); Matrix metalloprotienases (MMP7, MMP9, MMP12); components of the cornified envelope / squamous metaplasia (SPRR2a, SPRR2F).
Keywords
Chlamydia trachomatis; RNA isolation; Trachomatous conjunctival scarring| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment |
| Date | 1 August 2011 |
| Language(s) of written materials | English |
| Creator(s) |
Burton, MJ; Hu, V; Bauer, J; Mabey, D; Holland, MJ and Bailey, RL
|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 11 Jan 2019 10:14 |
| Last Modified | 08 Jul 2021 12:52 |
| Publisher | NCBI Gene Expression Omnibus |
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