The conjunctival transcriptome in scarring trachoma for Tanzanians

Burton, MJORCID logo, Hu, V, Bauer, J, Mabey, DORCID logo, Holland, MJORCID logo and Bailey, RLORCID logo (2011). The conjunctival transcriptome in scarring trachoma for Tanzanians. [Dataset]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24383
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Trachoma is a poorly understood immuno-fibrogenic disease process, initiated by Chlamydia trachomatis (Ct). Differences in conjunctival gene expression profiles between Tanzanians with trachomatous conjunctival scarring (with (TSI) and without (TS) inflammation) and controls (C) were investigated to identify relevant host responses. Tarsal conjunctival swab samples were collected for RNA isolation and Ct PCR. Transcriptome-wide microarray experiments were conducted on 41 samples (TSI 13, TS 15, C14). Cases had enrichment in proinflammatory cytokines and chemokines (IL1B, IL8, CXCL5, CCL20); Matrix metalloprotienases (MMP7, MMP9, MMP12); components of the cornified envelope / squamous metaplasia (SPRR2a, SPRR2F).

Keywords

Chlamydia trachomatis, RNA isolation, Trachomatous conjunctival scarring

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