Supplement to: "Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea"

Marks, M, Mitjà, O, Bottomley, C, Kwakye, C, Houinei, W, Bauri, M, Adwere, P, Abdulai, AA, Dua, F, Boateng, L, Wangi, J, Ohene, S, Wangnapi, R, Simpson, SV, Miag, H, Addo, KK, Basing, LA, Danavall, D, Chi, KH, Pillay, A, Ballard, R, Solomon, AW, Chen, CY, Bieb, SV, Adu-Sarkodie, Y, Mabey, DCW and Asiedu, K. 2018. Supplement to: "Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00000766.

Marks, M, Mitjà, O, Bottomley, C, Kwakye, C, Houinei, W, Bauri, M, Adwere, P, Abdulai, AA, Dua, F, Boateng, L, Wangi, J, Ohene, S, Wangnapi, R, Simpson, SV, Miag, H, Addo, KK, Basing, LA, Danavall, D, Chi, KH, Pillay, A, Ballard, R, Solomon, AW, Chen, CY, Bieb, SV, Adu-Sarkodie, Y, Mabey, DCW and Asiedu, K. Supplement to: "Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea". [Internet] LSHTM Data Compass. London, United Kingdom: London School of Hygiene & Tropical Medicine; 2018. Available from: https://doi.org/10.17037/DATA.00000766.

Marks, M, Mitjà, O, Bottomley, C, Kwakye, C, Houinei, W, Bauri, M, Adwere, P, Abdulai, AA, Dua, F, Boateng, L, Wangi, J, Ohene, S, Wangnapi, R, Simpson, SV, Miag, H, Addo, KK, Basing, LA, Danavall, D, Chi, KH, Pillay, A, Ballard, R, Solomon, AW, Chen, CY, Bieb, SV, Adu-Sarkodie, Y, Mabey, DCW and Asiedu, K (2018). Supplement to: "Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00000766.

Description

Description of data capture Eligible children were randomly assigned to either a low-dose (20 mg/kg, maximum 1 g) or standard-dose (30 mg/kg, maximum 2 g) group. Randomisation was performed in blocks of four, by use of a computer-generated random number sequence that was generated by the trial statistician (CB) at the London School of Hygiene & Tropical Medicine. Allocation was concealed from investigators by use of opaque, sealed, sequentially numbered envelopes that were opened after the study team had enrolled a participant. Health-care workers assessing clinical outcomes in the field were not masked to the patient's treatment group but patients and investigators performing statistical or laboratory analyses of samples were masked to treatment allocation. Study allocations are listed in appendix 2.
Data capture method Experiment: Field Intervention
Data Collection Period
FromTo
12 June 20152 July 2016
Date (Published in a 3rd party system) 15 February 2018
Geographical area covered
North LatitudeEast LongitudeSouth LatitudeWest Longitude
8.338220.5761668.209120.451197
5.9844-0.4851815.78223-0.751599
Language(s) of written materials English
Data Creators Marks, M, Mitjà, O, Bottomley, C, Kwakye, C, Houinei, W, Bauri, M, Adwere, P, Abdulai, AA, Dua, F, Boateng, L, Wangi, J, Ohene, S, Wangnapi, R, Simpson, SV, Miag, H, Addo, KK, Basing, LA, Danavall, D, Chi, KH, Pillay, A, Ballard, R, Solomon, AW, Chen, CY, Bieb, SV, Adu-Sarkodie, Y, Mabey, DCW and Asiedu, K
Associated roles Agana, N (Project Member), Ampadu, E (Project Member), Amponsah-Achiano, K (Project Member), Bediako, A (Project Member), Biredu, M (Project Member), Faried, K (Project Member), Iddrisu, A (Project Member), Kotey, NK (Project Member), Yeboah, GN (Project Member), El-Duah, P (Project Member), Phillips, R (Project Member), Binka, F (Project Member), Nyonator, F (Project Member), Zunuo, A (Project Member), Ackumey, MA (Project Member), Amanor, I (Project Member), Bnosu, C (Project Member), Frischmann, S (Project Member), Lammie, P (Project Member), Martin, D (Project Member), Ye, T (Project Member), Christophel, E (Project Member), Tiendrebeogo, A (Project Member), Vestergard, L (Project Member), Bassat, Q (Project Member), Abdad, Y (Project Member), Dima, H (Project Member), Kotty, B (Project Member), Mamore, K (Project Member), Manup, W (Project Member), Olowau, B (Project Member), Agyei, EO (Project Member), Agyemang, D (Project Member), Ako, EP (Project Member), Antwi, P (Project Member), Darko, J (Project Member), Darko, OO (Project Member), Darko, P (Project Member), Duodu, B (Project Member), Jabasi, D (Project Member), Karim, FL (Project Member), Koomson, OK (Project Member), Labri, BA (Project Member), Nartey, J (Project Member), Tamatey, R (Project Member), Yirenkyi, B (Project Member), Arhin, M (Project Member), Biney, F (Project Member), Danso, JO (Project Member), Dei, MA (Project Member), Djan, M (Project Member), Sasu, S (Project Member), Solomon, BA (Project Member), Torvinya, V (Project Member), Amankwaah, H (Project Member), Baffoe, J (Project Member), Djan, M (Project Member), Keteku, L (Project Member), Kondobala, K (Project Member), Lomotey, RD (Project Member), Nartey, AA (Project Member), Oppong, P (Project Member), Quainoo, MA (Project Member), Abotsi, T (Project Member), Agebshie, D (Project Member), Ameamu, A (Project Member), Angwaawie, P (Project Member), Ayibor, R (Project Member), Mwingmendeli, M (Project Member), Nakodia, J (Project Member), Nambagyira, A (Project Member), Nanga, D (Project Member), Dominic, N (Project Member) and Wanaom, A (Project Member)
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions London School of Hygiene & Tropical Medicine, London, United Kingdom, World Health Organization, Centers for Disease Control and Prevention, Kwame Nkrumah University of Science and Technology, Barcelona Institute for Global Health, Papua New Guinea Institute of Medical Research, Ghana Health Services, Noguchi Memorial Institute for Medical Research, Papua New Guinea National Department of Health, University of Health and Allied Sciences, Ho, Volta Region, Ghana
Funders
ProjectFunderGrant NumberFunder URI
Comparison of Two Different Doses of Azithromycin for Treatment of YawsCoalition for Operational Research on Neglected Tropical DiseasesUNSPECIFIEDUNSPECIFIED
Randomized Controlled Trial Comparing Efficacy of Single Dose Treatment of Yaws With 20mg/kg Versus 30mg/kg of AzithromycinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Depositor Gareth Knight
Date Deposited 02 Jul 2018 09:22
Last Modified 02 Jul 2018 10:54
Publisher London School of Hygiene & Tropical Medicine

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