A Metabolic Study of Huntington’s Disease

Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT. 2016. A Metabolic Study of Huntington’s Disease. [Online]. PLOS One. Available from: https://doi.org/10.1371/journal.pone.0146480.

Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT. A Metabolic Study of Huntington’s Disease. [Internet] LSHTM Data Compass. PLOS One; 2016. Available from: https://doi.org/10.1371/journal.pone.0146480.

Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT (2016). A Metabolic Study of Huntington’s Disease. [Data Collection]. PLOS One. https://doi.org/10.1371/journal.pone.0146480.

Description

Description of data capture Control (n = 15), premanifest (n = 14) and stage II/III (n = 13) participants were studied with blood sampling over a 24-hour period. A battery of clinical tests including neurological rating and function scales were performed. Visceral and subcutaneous adipose distribution was measured using magnetic resonance imaging. We quantified fasting baseline concentrations of glucose, insulin, cholesterol, triglycerides, lipoprotein (a), fatty acids, amino acids, lactate and osteokines. Leptin and ghrelin were quantified in fasting samples and after a standardised meal. We assessed glucose, insulin, growth hormone and cortisol concentrations during a prolonged oral glucose tolerance test.
Data capture method Experiment
Date (Published in a 3rd party system) 8 January 2016
Language(s) of written materials English
Data Creators Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C, Björkqvist, M and Warner, TT
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Participating Institutions London School of Hygiene & Tropical Medicine, University College London, Lund University, Necker Hospital, University of Oxford, Royal Free London NHS Foundation Trust, Fondazione CNR-Regione Toscana G, Imperial College
Funders
ProjectFunderGrant NumberFunder URI
UNSPECIFIEDCure Huntington's Disease InitiativeUNSPECIFIEDUNSPECIFIED
Depositor Gareth Knight
Date Deposited 14 Jan 2016 10:36
Last Modified 18 Jan 2019 00:30
Publisher PLOS One

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