A Metabolic Study of Huntington’s Disease

Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C

, Björkqvist, M and Warner, TT (2016). A Metabolic Study of Huntington’s Disease. [Dataset]. PLOS One. https://doi.org/10.1371/journal.pone.0146480

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Data produced as part of a study of metabolic factors in Huntington’s disease gene carriers. The study sought to determine whether various metabolic variables are linked to disease state in a cross-sectional study of cohorts of HD gene carriers and controls. The study team examined carbohydrate, lipid and protein metabolites as well as hormones related to energy metabolism in plasma samples from well-characterised cohorts of premanifest and moderate HD subjects and healthy controls.

Keywords

Huntington’s Disease, Metabolic factors

Item Type	Dataset
Description of data capture	Control (n = 15), premanifest (n = 14) and stage II/III (n = 13) participants were studied with blood sampling over a 24-hour period. A battery of clinical tests including neurological rating and function scales were performed. Visceral and subcutaneous adipose distribution was measured using magnetic resonance imaging. We quantified fasting baseline concentrations of glucose, insulin, cholesterol, triglycerides, lipoprotein (a), fatty acids, amino acids, lactate and osteokines. Leptin and ghrelin were quantified in fasting samples and after a standardised meal. We assessed glucose, insulin, growth hormone and cortisol concentrations during a prolonged oral glucose tolerance test.
Capture method	Experiment
Date	8 January 2016
Language(s) of written materials	English
Creator(s)	Nambron, R, Silajdžić, E, Kalliolia, E, Ottolenghi, C, Hindmarsh, P, Hill, NR, Costelloe, SJ, Martin, NG, Positano, V, Watt, HC, Frost, C , Björkqvist, M and Warner, TT
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Participating Institutions	London School of Hygiene & Tropical Medicine, University College London, Lund University, Necker Hospital, University of Oxford, Royal Free London NHS Foundation Trust, Fondazione CNR-Regione Toscana G, Imperial College
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Cure Huntington's Disease Initiative UNSPECIFIED UNSPECIFIED
Date Deposited	14 Jan 2016 10:36
Last Modified	08 Jul 2021 12:48
Publisher	PLOS One