Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Küpers, LK; Monnereau, C; Sharp, GC; Yousefi, P; Salas, LA; Ghantous, AG; Page, CM; Reese, SE; Wilcox, AJ; Czamara, D; Starling, AP; Novoloaca, A; Lent, S; Roy, R; Hoyo, C; Breton, CV; Allard, C; Just, AC; Bakulski, KM; Holloway, JW; Everson, TM; Xu, C; Huang, R; van der Plaat, DA; Wielscher, M; Kebede Merid, S; Ullemar, V; Rezwan, FI; Lahti, J; van Dongen, J; Langie, SA; Richardson, TG; Magnus, MC; Nohr, EA; Xu, Z; Duijts, L; Zhao, S; Zhang, W; Plusquin, M; DeMeo, DL; Solomon, O; Heimovaara, JH; Jima, DD; Gao, L; Bustamante, M; Perron, P; Wright, RO; Hertz-Picciotto, I; Zhang, H; Karagas, MR; Gehring, U; Marsit, CJ; Beilin, LJ; Vonk, JM; Jarvelin, M; Bergström, A; Örtqvist, AK; Ewart, S; Villa, PM; Moore, S; Willemsen, G; Standaert, AR; Håberg, SE; Sørensen, TI; Taylor, JA; Räikkönen, K; Yang, IV; Kechris, K; Nawrot, TS; Silver, MJ
; Gong, YY; Richiardi, L; Kogevinas, M; Litonjua, AA; Eskenazi, B; Huen, K; Mbarek, H; Maguire, RL; Dwyer, T; Vrijheid, M; Bouchard, L; Baccarelli, AA; Croen, LA; Karmaus, W; Anderson, D; de Vries, M; Sebert, S; Kere, J; Karlsson, R; Hasan Arshad, S; Hämäläinen, E; Routledge, MN; Boomsma, DI; Feinberg, AP; Newschaffer, CJ; Govarts, E; Moisse, M; Fallin, MD; Melén, E; Prentice, AM; Kajantie, E; Almqvist, C; Oken, E; Dabelea, D; Boezen, HM; Melton, PE; Wright, RJ; Koppelman, GH; Trevisi, L; Hivert, M; Sunyer, J; Munthe-Kaas, MC; Murphy, SK; Corpeleijn, E; Wiemels, J; Holland, N; Herceg, Z; Binder, EB; Smith, GD; Jaddoe, VW; Lie, RT; Nystad, W; London, SJ; Lawlor, DA; Relton, CL; Snieder, H and Felix, JF
(2019).
Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
[Dataset].
Zenodo.
https://doi.org/10.5281/zenodo.2222286
; Gong, YY; Richiardi, L; Kogevinas, M; Litonjua, AA; Eskenazi, B; Huen, K; Mbarek, H; Maguire, RL; Dwyer, T; Vrijheid, M; Bouchard, L; Baccarelli, AA; Croen, LA; Karmaus, W; Anderson, D; de Vries, M; Sebert, S; Kere, J; Karlsson, R; Hasan Arshad, S; Hämäläinen, E; Routledge, MN; Boomsma, DI; Feinberg, AP; Newschaffer, CJ; Govarts, E; Moisse, M; Fallin, MD; Melén, E; Prentice, AM; Kajantie, E; Almqvist, C; Oken, E; Dabelea, D; Boezen, HM; Melton, PE; Wright, RJ; Koppelman, GH; Trevisi, L; Hivert, M; Sunyer, J; Munthe-Kaas, MC; Murphy, SK; Corpeleijn, E; Wiemels, J; Holland, N; Herceg, Z; Binder, EB; Smith, GD; Jaddoe, VW; Lie, RT; Nystad, W; London, SJ; Lawlor, DA; Relton, CL; Snieder, H and Felix, JF
(2019).
Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
[Dataset].
Zenodo.
https://doi.org/10.5281/zenodo.2222286
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni<1.06x10-7).
Keywords
DNA methylation; EWAS; epigenome-wide association study; epigenetic epidemiology; Birthweight; DOHAD; PACE consortium; Childhood Epigenetics| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment |
| Date | 23 April 2019 |
| Language(s) of written materials | English |
| Creator(s) |
Küpers, LK; Monnereau, C; Sharp, GC; Yousefi, P; Salas, LA; Ghantous, AG; Page, CM; Reese, SE; Wilcox, AJ; Czamara, D; Starling, AP; Novoloaca, A; Lent, S; Roy, R; Hoyo, C; Breton, CV; Allard, C; Just, AC; Bakulski, KM; Holloway, JW; Everson, TM; Xu, C; Huang, R; van der Plaat, DA; Wielscher, M; Kebede Merid, S; Ullemar, V; Rezwan, FI; Lahti, J; van Dongen, J; Langie, SA; Richardson, TG; Magnus, MC; Nohr, EA; Xu, Z; Duijts, L; Zhao, S; Zhang, W; Plusquin, M; DeMeo, DL; Solomon, O; Heimovaara, JH; Jima, DD; Gao, L; Bustamante, M; Perron, P; Wright, RO; Hertz-Picciotto, I; Zhang, H; Karagas, MR; Gehring, U; Marsit, CJ; Beilin, LJ; Vonk, JM; Jarvelin, M; Bergström, A; Örtqvist, AK; Ewart, S; Villa, PM; Moore, S; Willemsen, G; Standaert, AR; Håberg, SE; Sørensen, TI; Taylor, JA; Räikkönen, K; Yang, IV; Kechris, K; Nawrot, TS; Silver, MJ; Gong, YY; Richiardi, L; Kogevinas, M; Litonjua, AA; Eskenazi, B; Huen, K; Mbarek, H; Maguire, RL; Dwyer, T; Vrijheid, M; Bouchard, L; Baccarelli, AA; Croen, LA; Karmaus, W; Anderson, D; de Vries, M; Sebert, S; Kere, J; Karlsson, R; Hasan Arshad, S; Hämäläinen, E; Routledge, MN; Boomsma, DI; Feinberg, AP; Newschaffer, CJ; Govarts, E; Moisse, M; Fallin, MD; Melén, E; Prentice, AM; Kajantie, E; Almqvist, C; Oken, E; Dabelea, D; Boezen, HM; Melton, PE; Wright, RJ; Koppelman, GH; Trevisi, L; Hivert, M; Sunyer, J; Munthe-Kaas, MC; Murphy, SK; Corpeleijn, E; Wiemels, J; Holland, N; Herceg, Z; Binder, EB; Smith, GD; Jaddoe, VW; Lie, RT; Nystad, W; London, SJ; Lawlor, DA; Relton, CL; Snieder, H and Felix, JF
|
| Research Centre | Centre for Maternal, Reproductive and Child Health (MARCH) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 22 Jul 2019 14:33 |
| Last Modified | 26 Jun 2025 11:18 |
| Publisher | Zenodo |
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