Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches

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Shitaye, G, Gadisa, E, Grignard, L, Shumie, G, Chali, W, Menberu, T, Belachew, M, Tegegn, G, Challi, S, Curry, J, Mahey, L, Hailu, T, Mamo, H, Menon, M, Balcha, T, Aseffa, A, Drakeley, C, Bousema, T and Tadesse, FG. 2018. Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches. [Online]. Figshare. Available from: - https://doi.org/10.6084/m9.figshare.c.4187285.v1

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8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in endemic countries since primaquine in G6PDd individuals may lead to acute haemolysis. In this study, the prevalence of G6PDd was investigated in different settings in Ethiopia using phenotyping and genotyping approaches. Collection consists of three files: File 1 is a flow chart for genotyping and data analysis. Indicated in a) is the schematic presentation of the quality check for data analysis and in b) is the genotyping procedure; File 2 contains KASP Primer sequences; and file 3 contains a Genotyping overview.

Published in a 3rd party system Date: 2 August 2018
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Data Creators(s): Shitaye, G, Gadisa, E, Grignard, L, Shumie, G, Chali, W, Menberu, T, Belachew, M, Tegegn, G, Challi, S, Curry, J, Mahey, L, Hailu, T, Mamo, H, Menon, M, Balcha, T, Aseffa, A, Drakeley, C, Bousema, T and Tadesse, FG
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom

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