Data from: Transmission of multidrug-resistant and drug-susceptible tuberculosis within households: a prospective cohort study

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Grandjean, L, Gilman, RH, Martin, L, Soto, E, Castro, B, Lopez, S, Coronel, J, Castillo, E, Alarcon, V, Lopez, V, San Miguel, A, Quispe, N, Asencios, L, Dye, C and Moore, D. 2015. Data from: Transmission of multidrug-resistant and drug-susceptible tuberculosis within households: a prospective cohort study. [Online]. Dryad Digital Repository. Available from: 10.5061/dryad.br760

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This 3 year prospective cohort household follow-up study in South Lima and Callao, Peru, measured the incidence of tuberculosis disease among 1,055 household contacts of 213 MDRTB index cases and 2,362 household contacts of 487 drug-susceptible index cases. A total of 35/1,055 (3.3%) household contacts of 213 MDRTB index cases developed tuberculosis disease, while 114/2,362 (4.8%) household contacts of 487 drug-susceptible index patients developed tuberculosis disease. The total follow-up time for drug-susceptible tuberculosis contacts was 2,620 person-years, while the total follow-up time for MDRTB contacts was 1,425 person-years. Using multivariate Cox regression to adjust for confounding variables including contact HIV status, contact age, socio-economic status, and index case sputum smear grade, the hazard ratio for tuberculosis disease among MDRTB household contacts was found to be half that for drug-susceptible contacts (hazard ratio 0.56, 95% CI 0.34–0.90, p = 0.017). The inference of transmission in this study was limited by the lack of genotyping data for household contacts. Capturing incident disease only among household contacts may also limit the extrapolation of these findings to the community setting. It concluded that the low relative fitness of MDRTB estimated by this study improves the chances of controlling drug-resistant tuberculosis. However, fitter multidrug-resistant strains that emerge over time may make this increasingly difficult.

Published in a 3rd party system Date: 23 June 2015
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Data Creators(s): Grandjean, L, Gilman, RH, Martin, L, Soto, E, Castro, B, Lopez, S, Coronel, J, Castillo, E, Alarcon, V, Lopez, V, San Miguel, A, Quispe, N, Asencios, L, Dye, C and Moore, D
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
Participating Institutions: London School of Hygiene & Tropical Medicine, London, Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, Universidad Peruana Cayetano Heredia, Lima, Peru, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Laboratorio de Mycobacteriologia, Dirección Regional de Salud–Región Callao, Lima, Peru, Unidad Técnica de TB-MDR, Ministerio de Salud, Lima, Peru, Estrategia Sanitaria Nacional de Prevención y Control de la Tuberculosis and Laboratorio de Mycobacteriologia, Dirección de Salud II–Lima Sur, Lima, Peru, Instituto Nacional de Salud, Lima, Peru, Office for HIV/AIDS, Malaria, Tuberculosis and Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland, Universidad Peruana Cayetano Heredia, Lima, Peru

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