Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates

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Ugarte-Ruiz, M, Stabler, R, Domínguez, L, Domínguez, L, Wren, B, Dorrell, N and Gundogdu, O. 2015. Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates. [Online]. National Center for Biotechnology Information. Available from: http://datacompass.lshtm.ac.uk/106/ http://trace.ncbi.nlm.nih.gov/Traces/sra/?study=ERP012241

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Infections from Campylobacter jejuni pose a serious public health problem and are now considered the leading cause of foodborne bacterial gastroenteritis throughout the world. Sequencing of C. jejuni genomes has previously allowed a number of loci to be identified, which encode virulence factors that aid survival and pathogenicity. Recently, a Type VI secretion system (T6SS) consisting of 13 conserved genes was described in C. jejuni strains and recognised to promote pathogenicity and adaptation to the environment. In this study, we determined the presence of this T6SS in 63 Spanish C. jejuni isolates from the food chain and urban effluents using whole-genome sequencing. Our findings demonstrated that nine (14%) strains harboured the 13 ORFs found in prototype strain C. jejuni 108. Further studies will be necessary to determine the prevalence and importance of T6SS-positive C. jejuni strains.

Published in a 3rd party system Date: 23 September 2015
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Data Creators(s): Ugarte-Ruiz, M, Stabler, R, Domínguez, L, Domínguez, L, Wren, B, Dorrell, N and Gundogdu, O
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Participating Institutions: London School of Hygiene & Tropical Medicine, VISAVET Health Surveillance Centre, Complutense University of Madrid

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