Fletcher, HA, Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA. 2014. PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease. [Online]. NCBI Gene Expression Omnibus. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20716
Fletcher, HA, Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA. PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease [Internet]. NCBI Gene Expression Omnibus; 2014. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20716
Fletcher, HA, Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA (2014). PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease. [Data Collection]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20716
Description
Analysis of PBMC from 10 week old infants vaccinated with BCG at birth. During follow-up 26 infants developed tuberculosis (TB) (non-protected by BCG) and 20 infants did not develop TB despite documented exposure (protected by BCG). PBMC were stimulated with media only or reconstituted BCG for 4 and 12 hours. Results provide insight into the mechanisms behind the failure of BCG to protect against disease.
Keywords
| Data capture method | Experiment |
|---|---|
| Date (Date published in a 3rd party system) | 30 June 2014 |
| Language(s) of written materials | English |
| Data Creators | Fletcher, HA, Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA |
|---|---|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 11 Jan 2019 10:06 |
|---|---|
| Last Modified | 08 Jul 2021 12:49 |
| Publisher | NCBI Gene Expression Omnibus |
