Safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda: randomised controlled trial
; Levin, J; Abaasa, A; Nunn, A; Grosskurth, H and Munderi, P
(2018).
Safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda: randomised controlled trial.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00000917.
Cotrimoxazole (CTX) prophylaxis is recommended by the World Health Organisation for HIV infected persons. However, once HIV infected patients have commenced anti-retroviral treatment (ART), the benefits of continued CTX prophylaxis are not known. The COSTOP randomised controlled trial sought to assess the efficacy and safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda. This data collection contains 12 individual-level datasets associated with the study. It covers: time to the first clinical event; time to first grade 3-4 laboratory adverse event; Adherence to CTX, ART and ITN; all-cause mortality; all grade 3-4 haematological adverse events; laboratory parameters and CD4 counts at week 48; number of episodes of haematological grade 3-4 AEs; time to first hospital admission; and a sensitivity analysis.
Additional Information
The depositors confirm that the datasets have been fully anonymised and that ethics issues have been addressed prior to sharing. Queries will be handled by the following people: [1] Zacchaeus Anywaine; [2] Jonathan Levin; [3] Heiner Grosskurth; and [4] Ayoub Kakande.
Keywords
Cotrimoxazole prophylaxis; HIV infections; HIV positive; Anti-retroviral treatment; Randomised controlled trial| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Questionnaire: Fixed form - Paper, Measurements and tests |
| Collection Period |
From To 3 January 2011 30 June 2014 |
| Date | 6 October 2018 |
| Geographical area covered (offline during plugin upgrade) |
North East South West 0.402315 32.6896 -0.981911 30.9153 |
| Language(s) of written materials | English |
| Creator(s) |
Anywaine, Z; Levin, J; Abaasa, A; Nunn, A; Grosskurth, H and Munderi, P
|
| Associated roles | Kakande, A; Kayiira Lutaakome, J (Researcher) and Kasirye, R (Researcher) |
| LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
| Research Centre | International Statistics and Epidemiology Group |
| Participating Institutions | MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda; London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Safety of discontinuing Cotrimoxazole prophylaxis among HIV infected adults on ART in Uganda. A randomised controlled trial (COSTOP) G0902150 http://dx.doi.org/10.13039/501100000265 Safety of discontinuing Cotrimoxazole prophylaxis among HIV infected adults on ART in Uganda. A randomised controlled trial (COSTOP) UNSPECIFIED http://dx.doi.org/10.13039/501100000278 Safety of discontinuing Cotrimoxazole prophylaxis among HIV infected adults on ART in Uganda. A randomised controlled trial (COSTOP) UNSPECIFIED http://dx.doi.org/10.13039/501100001713 Safety of discontinuing Cotrimoxazole prophylaxis among HIV infected adults on ART in Uganda. A randomised controlled trial (COSTOP) UNSPECIFIED http://dx.doi.org/10.13039/501100000780 |
| Date Deposited | 05 Nov 2018 15:35 |
| Last Modified | 24 Feb 2026 13:24 |
| Publisher | London School of Hygiene & Tropical Medicine |
Explore Further
- Safety of discontinuing Cotrimoxazole prophylaxis among HIV infected adults on anti-retroviral therapy in Uganda (COSTOP Trial): Design.
- Effect of antiretroviral therapy on malaria incidence in HIV-infected Ugandan adults
- Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda.
- Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda.
Data / Code
-
subject - Data
-
lock - Restricted to Request access for all
-
copyright - Available under Data Sharing Agreement
-
info - 11 anonymised datasets held in CSV format
folder_zip - application/zip
- folder_info
- 241B
Documentation
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subject - Documentation
-
- Available under Creative Commons: Attribution 3.0
-
info - User guide for COSTOP datasets - see codebook for details
html - text/html
- folder_info
- 5kB
-
subject - Documentation
-
- Available under Creative Commons: Attribution 3.0
-
info - Codebook for COSTOP datasets
html - text/html
- folder_info
- 33kB
