Anywaine, Z, Levin, J, Abaasa, A, Nunn, A, Grosskurth, H and Munderi, P. 2018. Safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda: randomised controlled trial. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00000917.
Anywaine, Z, Levin, J, Abaasa, A, Nunn, A, Grosskurth, H and Munderi, P. Safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda: randomised controlled trial [Internet]. London School of Hygiene & Tropical Medicine; 2018. Available from: https://doi.org/10.17037/DATA.00000917.
Anywaine, Z, Levin, J, Abaasa, A, Nunn, A, Grosskurth, H and Munderi, P (2018). Safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda: randomised controlled trial. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00000917.
Description
Cotrimoxazole (CTX) prophylaxis is recommended by the World Health Organisation for HIV infected persons. However, once HIV infected patients have commenced anti-retroviral treatment (ART), the benefits of continued CTX prophylaxis are not known. The COSTOP randomised controlled trial sought to assess the efficacy and safety of discontinuing cotrimoxazole prophylaxis among HIV infected adults stabilized on ART in Uganda. This data collection contains 12 individual-level datasets associated with the study. It covers: time to the first clinical event; time to first grade 3-4 laboratory adverse event; Adherence to CTX, ART and ITN; all-cause mortality; all grade 3-4 haematological adverse events; laboratory parameters and CD4 counts at week 48; number of episodes of haematological grade 3-4 AEs; time to first hospital admission; and a sensitivity analysis.
Additional information
The depositors confirm that the datasets have been fully anonymised and that ethics issues have been addressed prior to sharing. Queries will be handled by the following people: [1] Zacchaeus Anywaine; [2] Jonathan Levin; [3] Heiner Grosskurth; and [4] Ayoub Kakande.
Data capture method | Questionnaire: Fixed form - Paper, Measurements and tests | ||||||||
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Data Collection Period |
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Date (Date submitted to LSHTM repository) | 6 October 2018 | ||||||||
Geographical area covered (offline during plugin upgrade) |
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Language(s) of written materials | English |
Data Creators | Anywaine, Z, Levin, J, Abaasa, A, Nunn, A, Grosskurth, H and Munderi, P |
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Associated roles | Kakande, A, Kayiira Lutaakome, J (Researcher) and Kasirye, R (Researcher) |
LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
Research Centre | Tropical Epidemiology Group |
Participating Institutions | MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda, London School of Hygiene & Tropical Medicine, London, United Kingdom |
Funders |
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Date Deposited | 05 Nov 2018 15:35 |
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Last Modified | 05 Apr 2022 18:18 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data / Code
Restricted to: Request access for all
Filename: COSTOP_dataset.zip
Description: 11 anonymised datasets held in CSV format
Content type: Dataset
File size: 345kB
Mime-Type: application/zip
Documentation
Filename: UserGuide.html
Description: User guide for COSTOP datasets - see codebook for details
Content type: Textual content
File size: 5kB
Mime-Type: text/html