PFAS–microbiome systems analysis of the Ronneby cohort: processed statistical and metabolic-modelling tables

This dataset provides processed statistical and computational outputs supporting the study Integrated gut microbiome analyses prioritize candidate microbial processes associated with longitudinal PFAS elimination in a highly exposed human cohort. The study integrates shotgun metagenomic profiles from 65 participants in the Ronneby, Sweden cohort, including 47 historically PFAS-exposed individuals and 18 regional reference participants. Analyses combine MetaPhlAn taxonomic profiling, HUMAnN functional pathways, AGORA2-derived metabolic modelling features, statistical association testing, machine-learning prioritisation and metagenome-assembled genome (MAG) context. The deposited tables support reproducibility and interpretation of the reported taxonomic, functional and metabolic analyses. Results are primarily exploratory and do not establish a validated microbial biomarker of PFAS elimination or demonstrate microbial PFAS degradation. Original human-associated sequencing reads and restricted participant-level PFAS and clinical data are excluded. The separate MAG deposition is associated with NCBI BioProject PRJNA1522707. Analysis code is available at https://github.com/PoeticPremium6/PFAS-Microbiome. Approved original processed data are licensed under Creative Commons Attribution 4.0 International (CC BY 4.0), subject to applicable third-party rights.

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