Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis
Tabular data associated with a comparative Transcriptome analysis of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis. This includes details of primers used for RTqPCR TLDA Experiment; demographic, clinical, and microbiological data for microarray participants; a list of differentially expressed genes, fold changes, and false-discovery rate (FDR) adjusted p-values in the three microarray pairwise comparisons (FK vs. C, BK vs. C, and BK vs. FK); gene ontology enrichment analysis for the differentially expressed genes common to both bacterial and fungal keratitis: biological process (BP_FAT), molecular function (MF_FAT), and cellular component (CC_FAT) terms from DAVID v6.8; gene ontology term enrichment analysis for each of the seven most highly connected gene clusters in the network co-expression analysis (using DAVID v6.8). Normalized expression intensities of all differentially expressed genes in the bacterial and fungal keratitis vs. control comparisons used to create network graph in Miru).; and a comparison of early stage samples from the validation cohort (symptom duration ≤7 days) with microarray tissue samples.
Keywords
Keratitis; Corneal ulcer; Fungi; Bacteria; Transcriptome; Streptococcus; Aspergillus; FusariumItem Type | Dataset |
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Resource Type |
Resource Type Resource Description Dataset Quantitative |
Capture method | Lab observation |
Date | 18 May 2017 |
Language(s) of written materials | English |
Creator(s) |
Chidambaram, JD, Kannambath, S, Srikanthi, P, Shah, M, Lalitha, P, Elakkiya, S, Bauer, J, Prajna, NV, Holland, MJ |
LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Participating Institutions | London School of Hygiene and Tropical Medicine, London, United Kingdom; St. George's University of London, London, United Kingdom; Aravind Eye Hospital, Madurai, India; Aravind Medical Research Foundation, Madurai, India; University of Cambridge, Cambridge, United Kingdom |
Funders |
Project Funder Grant Number Funder URI |
Date Deposited | 24 Aug 2017 09:23 |
Last Modified | 27 Apr 2022 18:20 |
Publisher | Frontiers in Cellular and Infection Microbiology |
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