Data supporting "BCG vaccination attenuates Schistosoma mansoni-associated rural–urban immune variation"
Nkurunungi, G
(2026).
Data supporting "BCG vaccination attenuates Schistosoma mansoni-associated rural–urban immune variation".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005340.
(2026).
Data supporting "BCG vaccination attenuates Schistosoma mansoni-associated rural–urban immune variation".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005340.
This dataset comprises individual-level data from 67 participants in the POPVAC A and POPVAC C randomised controlled trials. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting). POPVAC C was undertaken in Entebbe municipality among participants of the Entebbe Mother and Baby Study (EMaBS) cohort. Variables include data on socio-demographic characteristics, S. mansoni infection, and immune cluster frequencies (cell counts as a proportion of total live CD45+ PBMCs per sample) from mass cytometry experiments conducted on peripheral blood mononuclear cells from POPVAC participants.
Additional Information
To access the data, requests must be made to the POPVAC trial PI (Professor Alison Elliott) or to Dr Gyaviira Nkurunungi. The request will be reviewed by them together with the POPVAC investigator team. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
Keywords
CyTOF; Mass cytometry; BCG; Schistosoma mansoni; Uganda; Helminth infection; Trained Immunity| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Questionnaire: Fixed form, Lab observation, Measurements and tests |
| Collection Period |
From To 1 July 2019 24 July 2026 |
| Date | 24 July 2026 |
| Language(s) of written materials | English |
| Creator(s) |
Nkurunungi, G
|
| Associated roles | Walusimbi, B (Researcher); Webb, E (Researcher); Elliott, AM (Researcher) and Nassuuna, J (Researcher) |
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research MRC/UVRI and LSHTM Uganda Research Unit > UG-Co-Infections |
| Research Group | Immunomodulation and Vaccines Group |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda |
| Funders |
Project Funder Grant Number Funder URI The impact of differential parasite exposure on immunological and metabolic predictors of vaccine response in the tropics 224263/Z/21/Z https://doi.org/10.13039/100010269 |
| Date Deposited | 24 Jul 2026 13:15 |
| Last Modified | 24 Jul 2026 13:18 |
| Publisher | London School of Hygiene & Tropical Medicine |
Data / Code
cytof_data.zip
-
subject - Data
-
lock - Restricted to Request access for all
-
copyright - Available under Data Sharing Agreement
-
info - Data on S. mansoni infection and immune phenotypes (mass cytometry, unstimulated and PMA/ionomycin-stimulated panel) from the POPVAC A and C trial participants
folder_zip - application/zip
- folder_info
- 213B
Documentation
cytof_data_codebook.html
-
subject - Documentation
-
- Available under Creative Commons: Attribution 4.0
-
info - Codebook for CyTOF data on PMA/ionomycin-stimulated panel and unstimulated panel
html - text/html
- folder_info
- 51kB
Downloads
