Data from: Impact of directly observed treatment and extended age-range of seasonal malaria chemoprevention with sulfadoxine–pyrimethamine plus amodiaquine in Burkina Faso: A three-arm, open-label, cluster-randomized, controlled trial

Seasonal Malaria Chemoprevention (SMC) currently targets children below 5 years (< 5 yr). It is unclear what the impact of extending SMC to a wider age range will be. We conducted a cluster-randomized trial in Saponé (Burkina Faso) with three study arms: 1) Programmatic SMC-control arm: SMC in children < 5 years; 2) SMC in children < 5 years, with directly observed treatment (DOTu5); 3) SMC in children < 10 years with DOT (DOTu10). The trial involved 61 (programmatic SMC) and 62 (each DOT arms) clusters of 3 compounds (i.e., 183-186 compounds per arm). The primary endpoint was P. falciparum parasite prevalence at the end of the transmission season; secondary endpoints included clinical malaria incidence, drug plasma levels, and gametocyte prevalence. This trial is complete and is registered with ClinicalTrials.gov, NCT05878366.

Additional Information

Data for 75 participants (children and adolescents) who had been exposed to a household TB contact. They had subsequently been categorised as having active TB disease, LTBI (Mtb sensitisation), or no evidence of TB. CMV seropositivity and CMV IgG levels were obtained for these patients.

Keywords

Chemoprevention; Clinical trials; Cluster trials; Malaria; Medical and health sciences