Whole-genome sequencing illuminates the evolution and spread of multidrug-resistant tuberculosis in Southwest Nigeria

Senghore, M; Otu, J; Witney, A; Gehre, F; Doughty, EL; Kay, GL; Butcher, P; Salako, K; Kehinde, A; Onyejepu, N; Idigbe, E; Corrah, T; de Jong, B; Pallen, MJ and Antonio, M

(2017). Whole-genome sequencing illuminates the evolution and spread of multidrug-resistant tuberculosis in Southwest Nigeria. [Dataset]. PLOS ONE. https://doi.org/10.1371/journal.pone.0184510.s001

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This dataset consists of two files: (1) a spreadsheet containing Isolates metadata that covers study site, age, sex, treatment status (study case), HIV status, MDR & pre-XDR status, as well as lineage information inferred from kvarq, phyressse (Phy) and TBProfiler (tbp); and (2) a spreadsheet that contains phenotypic resistance profiles to first line drugs (rifampicin, isoniazid, streptomycin and ethambutol) for all isolates and to second line drugs (capreomycin, fluoroquinolone, ethionamide and amikacin) for MDR isolates. Table also lists presence of known resistance mutations as detected by the three resistance prediction tools kvarq, phyrese and tbprofiler.

Keywords

MDR-TB; multidrug-resistant tuberculosis; Whole-genome sequencing; Cameroon clade; multi-drug resistance; Southwest Nigeria; Nigeria

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Unknown
Date	20 September 2017
Language(s) of written materials	English
Creator(s)	Senghore, M; Otu, J; Witney, A; Gehre, F; Doughty, EL; Kay, GL; Butcher, P; Salako, K; Kehinde, A; Onyejepu, N; Idigbe, E; Corrah, T; de Jong, B; Pallen, MJ and Antonio, M
LSHTM Faculty/Department	MRC Unit The Gambia at LSHTM
Participating Institutions	MRC Unit The Gambia at LSHTM, Fajara, Banjul, The Gambia
Date Deposited	27 Nov 2024 16:10
Last Modified	06 May 2026 14:49
Publisher	PLOS ONE