Additional file 2 of A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping
Wen, Q
; Kim, C; Hamilton, P and Zhang, S
(2016).
Additional file 2 of A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping.
[Dataset].
Figshare.
https://doi.org/10.6084/m9.figshare.c.3624356_D2.v1
; Kim, C; Hamilton, P and Zhang, S
(2016).
Additional file 2 of A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping.
[Dataset].
Figshare.
https://doi.org/10.6084/m9.figshare.c.3624356_D2.v1
Significant drugs returned with the k=50 HDACi gene signature. The list of significant drugs returned from sscMap using the k=50 HDACi gene signature from the "simulated experiment". All 7 known HDAC inhibitors were pulled out, but together with many other drugs, which may or may not related to HDAC inhibition. The main biological theme (HDAC inhibition) could potentially be weakned or even masked due to the co-existence of many other drugs.
Keywords
Connectivity mapping; Differentially expressed genes; Gene signature progression; Disease inhibitory compounds; Lung cancer; Breast cancer| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Unknown |
| Date | 11 May 2016 |
| Language(s) of written materials | English |
| Creator(s) |
Wen, Q; Kim, C; Hamilton, P and Zhang, S
|
| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
| Participating Institutions | Queen’s University Belfast, Belfast, United Kingdom; STFC Daresbury Laboratory, Daresbury, Warrington, United Kingdom; University of Ulster, Altnagelvin Hospital campus, Derry/Londonderry, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Doctoral Training Grant UNSPECIFIED http://dx.doi.org/10.13039/501100000266 UNSPECIFIED BB/I009051/1 http://dx.doi.org/10.13039/501100000268 People Programme (Marie Curie Actions) UNSPECIFIED http://dx.doi.org/10.13039/100011102 |
| Date Deposited | 04 Jan 2024 17:09 |
| Last Modified | 04 Jan 2024 17:09 |
| Publisher | Figshare |
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