Additional file 1 of Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study

Additional file 1. S1. Exposure instruments to proxy hormone levels in the overall breast cancer incidence MR analysis. S2. The strength of the instruments for each hormone including the variance explained and the F statistic. S3. Hormone and breast cancer incidence associations using the alternative MR methods: MR Egger, weighted median, weighted mode and MR-RAPS. S4. MR intercept calculations to identify evidence of pleiotropy. S5. Genetic correlation results between hormones. S6. Exposure instruments to proxy hormone levels in the subtype specific MR analysis. S7. Exposure instruments to proxy hormone levels in the BRCA1 mutated TNBC MR analysis. S8. Power calculations for each hormone and overall and subtype specific BC analysis.

Keywords

Sex steroid hormones, Breast cancer, Mendelian randomization